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CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. Affandi AJ, et al. Among authors: brandt mm. Cell Rep. 2022 Jan 4;38(1):110189. doi: 10.1016/j.celrep.2021.110189. Cell Rep. 2022. PMID: 34986347 Free article.
Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction.
Nguyen ITN, Brandt MM, van de Wouw J, van Drie RWA, Wesseling M, Cramer MJ, de Jager SCA, Merkus D, Duncker DJ, Cheng C, Joles JA, Verhaar MC. Nguyen ITN, et al. Among authors: brandt mm. PLoS One. 2020 May 6;15(5):e0232399. doi: 10.1371/journal.pone.0232399. eCollection 2020. PLoS One. 2020. PMID: 32374790 Free PMC article.
Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome.
van Dijk CG, Oosterhuis NR, Xu YJ, Brandt M, Paulus WJ, van Heerebeek L, Duncker DJ, Verhaar MC, Fontoura D, Lourenço AP, Leite-Moreira AF, Falcão-Pires I, Joles JA, Cheng C. van Dijk CG, et al. Circ Heart Fail. 2016 Apr;9(4):e002760. doi: 10.1161/CIRCHEARTFAILURE.115.002760. Circ Heart Fail. 2016. PMID: 27056881
THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE-/- mice.
Haasdijk RA, Den Dekker WK, Cheng C, Tempel D, Szulcek R, Bos FL, Hermkens DM, Chrifi I, Brandt MM, Van Dijk C, Xu YJ, Van De Kamp EH, Blonden LA, Van Bezu J, Sluimer JC, Biessen EA, Van Nieuw Amerongen GP, Duckers HJ. Haasdijk RA, et al. Among authors: brandt mm. Cardiovasc Res. 2016 May 1;110(1):129-39. doi: 10.1093/cvr/cvw015. Epub 2016 Jan 27. Cardiovasc Res. 2016. PMID: 26822228
68 results