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An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.
Delbart F, Brams M, Gruss F, Noppen S, Peigneur S, Boland S, Chaltin P, Brandao-Neto J, von Delft F, Touw WG, Joosten RP, Liekens S, Tytgat J, Ulens C. Delbart F, et al. Among authors: brams m. J Biol Chem. 2018 Feb 16;293(7):2534-2545. doi: 10.1074/jbc.M117.815316. Epub 2017 Dec 13. J Biol Chem. 2018. PMID: 29237730 Free PMC article.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Spurny R, et al. Among authors: brams m. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035248 Free PMC article.
Structural basis of ligand recognition in 5-HT3 receptors.
Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C. Kesters D, et al. Among authors: brams m. EMBO Rep. 2013 Jan;14(1):49-56. doi: 10.1038/embor.2012.189. Epub 2012 Nov 30. EMBO Rep. 2013. PMID: 23196367 Free PMC article.
Family of prokaryote cyclic nucleotide-modulated ion channels.
Brams M, Kusch J, Spurny R, Benndorf K, Ulens C. Brams M, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7855-60. doi: 10.1073/pnas.1401917111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821777 Free PMC article.
Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealed by intrinsic tryptophan fluorescence quenching.
Billen B, Brams M, Debaveye S, Remeeva A, Alpizar YA, Waelkens E, Kreir M, Brüggemann A, Talavera K, Nilius B, Voets T, Ulens C. Billen B, et al. Among authors: brams m. J Biol Chem. 2015 May 15;290(20):12964-74. doi: 10.1074/jbc.M114.628925. Epub 2015 Mar 31. J Biol Chem. 2015. PMID: 25829496 Free PMC article.
68 results