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CD20-directed small modular immunopharmaceutical, TRU-015, depletes normal and malignant B cells.
Hayden-Ledbetter MS, Cerveny CG, Espling E, Brady WA, Grosmaire LS, Tan P, Bader R, Slater S, Nilsson CA, Barone DS, Simon A, Bradley C, Thompson PA, Wahl AF, Ledbetter JA. Hayden-Ledbetter MS, et al. Among authors: brady wa. Clin Cancer Res. 2009 Apr 15;15(8):2739-46. doi: 10.1158/1078-0432.CCR-08-1694. Epub 2009 Apr 7. Clin Cancer Res. 2009. PMID: 19351771
Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.
Nickerson-Nutter C, Tchistiakova L, Seth NP, Kasaian M, Sibley B, Olland S, Zollner R, Brady WA, Mohler KM, Baum P, Wahl A, Herber D, Vugmeyster Y, Wensel D, Wolfman NM, Gill D, Collins M, Dunussi-Joannopoulos K. Nickerson-Nutter C, et al. Among authors: brady wa. Rheumatology (Oxford). 2011 Jun;50(6):1033-44. doi: 10.1093/rheumatology/keq423. Epub 2011 Jan 21. Rheumatology (Oxford). 2011. PMID: 21258049 Free PMC article.
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