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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: bradley e. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Hirata K, Kotoku M, Seki N, Maeba T, Maeda K, Hirashima S, Sakai T, Obika S, Hori A, Hase Y, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Asahina K, Aratsu Y, Kamada M, Adachi T, Noguchi M, Doi S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Hashimoto H, Shiozaki M. Hirata K, et al. Among authors: bradley e. ACS Med Chem Lett. 2015 Nov 4;7(1):23-7. doi: 10.1021/acsmedchemlett.5b00253. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819660 Free PMC article.
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.
Noguchi M, Nomura A, Murase K, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Steensma R, Li X, Tao H, Tse B, Fenn M, Babine R, Bradley E, Crowe P, Thacher S, Adachi T, Kamada M. Noguchi M, et al. Among authors: bradley e. Genes Cells. 2017 Jun;22(6):535-551. doi: 10.1111/gtc.12494. Epub 2017 May 11. Genes Cells. 2017. PMID: 28493531 Free article.
National, regional, and global estimates of low birthweight in 2020, with trends from 2000: a systematic analysis.
Okwaraji YB, Krasevec J, Bradley E, Conkle J, Stevens GA, Gatica-Domínguez G, Ohuma EO, Coffey C, Estevez Fernandez DG, Blencowe H, Kimathi B, Moller AB, Lewin A, Hussain-Alkhateeb L, Dalmiya N, Lawn JE, Borghi E, Hayashi C. Okwaraji YB, et al. Among authors: bradley e. Lancet. 2024 Mar 16;403(10431):1071-1080. doi: 10.1016/S0140-6736(23)01198-4. Epub 2024 Feb 28. Lancet. 2024. PMID: 38430921 Free article.
Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation.
Jariwala N, Ozols M, Eckersley A, Mambwe B, Watson REB, Zeef L, Gilmore A, Debelle L, Bell M, Bradley EJ, Doush Y, Keenan A, Courage C, Leroux R, Peschard O, Mondon P, Ringenbach C, Bernard L, Pitois A, Sherratt MJ. Jariwala N, et al. Among authors: bradley ej. Br J Dermatol. 2024 Feb 20:ljae061. doi: 10.1093/bjd/ljae061. Online ahead of print. Br J Dermatol. 2024. PMID: 38375775
Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England.
Tajuria G, Dobel-Ober D, Bradley E, Charnley C, Lambley-Burke R, Mallen C, Honeyford K, Kingstone T. Tajuria G, et al. Among authors: bradley e. BMC Med Educ. 2024 Feb 8;24(1):126. doi: 10.1186/s12909-024-05059-0. BMC Med Educ. 2024. PMID: 38331811 Free PMC article.
1,458 results