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A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
J Med Chem. 2010 Dec 23;53(24):8508-22. doi: 10.1021/jm100732t. Epub 2010 Nov 16.
J Med Chem. 2010.
PMID: 21080703
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AG, Coombes RC.
Ali S, et al. Among authors: brackow j.
Cancer Res. 2009 Aug 1;69(15):6208-15. doi: 10.1158/0008-5472.CAN-09-0301. Epub 2009 Jul 28.
Cancer Res. 2009.
PMID: 19638587
Free PMC article.
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Biomimetic synthesis of resorcylate natural products utilizing late stage aromatization: concise total syntheses of the marine antifungal agents 15G256iota and 15G256beta.
Navarro I, Basset JF, Hebbe S, Major SM, Werner T, Howsham C, Bräckow J, Barrett AG.
Navarro I, et al. Among authors: brackow j.
J Am Chem Soc. 2008 Aug 6;130(31):10293-8. doi: 10.1021/ja803445u. Epub 2008 Jul 9.
J Am Chem Soc. 2008.
PMID: 18611011
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Electrostatic bubbles and supramolecular assistance of photosensitization by carboxylated Ru(II) complexes.
Potvin PG, Luyen PU, Bräckow J.
Potvin PG, et al. Among authors: brackow j.
J Am Chem Soc. 2003 Apr 23;125(16):4894-906. doi: 10.1021/ja028671f.
J Am Chem Soc. 2003.
PMID: 12696909
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