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Circulating uridine dynamically and adaptively regulates food intake in humans.
Hanssen R, Rigoux L, Albus K, Kretschmer AC, Edwin Thanarajah S, Chen W, Hinze Y, Giavalisco P, Steculorum SM, Cornely OA, Brüning JC, Tittgemeyer M. Hanssen R, et al. Among authors: bruning jc. Cell Rep Med. 2023 Jan 17;4(1):100897. doi: 10.1016/j.xcrm.2022.100897. Cell Rep Med. 2023. PMID: 36652907 Free PMC article.
Habitual daily intake of a sweet and fatty snack modulates reward processing in humans.
Edwin Thanarajah S, DiFeliceantonio AG, Albus K, Kuzmanovic B, Rigoux L, Iglesias S, Hanßen R, Schlamann M, Cornely OA, Brüning JC, Tittgemeyer M, Small DM. Edwin Thanarajah S, et al. Among authors: bruning jc. Cell Metab. 2023 Apr 4;35(4):571-584.e6. doi: 10.1016/j.cmet.2023.02.015. Epub 2023 Mar 22. Cell Metab. 2023. PMID: 36958330 Free article. Clinical Trial.
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation.
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Giavalisco P, Brüning JC. Chen W, et al. Among authors: bruning jc. Cell Metab. 2023 May 2;35(5):786-806.e13. doi: 10.1016/j.cmet.2023.03.019. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075752 Free PMC article.
Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor.
Engström Ruud L, Font-Gironès F, Zajdel J, Kern L, Teixidor-Deulofeu J, Mannerås-Holm L, Carreras A, Becattini B, Björefeldt A, Hanse E, Fenselau H, Solinas G, Brüning JC, Wunderlich TF, Bäckhed F, Ruud J. Engström Ruud L, et al. Among authors: bruning jc. Cell Rep. 2024 Apr 23;43(4):113960. doi: 10.1016/j.celrep.2024.113960. Epub 2024 Mar 19. Cell Rep. 2024. PMID: 38507407 Free article.
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.
Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. Griess K, et al. Among authors: bruning jc. Nat Cell Biol. 2023 Jan;25(1):20-29. doi: 10.1038/s41556-022-01027-2. Epub 2022 Dec 21. Nat Cell Biol. 2023. PMID: 36543979 Free PMC article.
Development of a genetically-encoded sensor for probing endogenous nociceptin opioid peptide release.
Zhou X, Stine C, Prada PO, Fusca D, Assoumou K, Dernic J, Bhat MA, Achanta AS, Johnson JC, Jadhav S, Bauder CA, Steuernagel L, Ravotto L, Benke D, Weber B, Stoeber M, Kloppenburg P, Brüning JC, Bruchas MR, Patriarchi T. Zhou X, et al. Among authors: bruning jc. bioRxiv [Preprint]. 2023 Jun 1:2023.05.26.542102. doi: 10.1101/2023.05.26.542102. bioRxiv. 2023. PMID: 37292957 Free PMC article. Preprint.
Depletion of TBC1D4 improves the metabolic exercise response by overcoming genetically induced peripheral insulin resistance.
Springer C, Binsch C, Weide D, Toska L, Cremer AL, Backes H, Scheel AK, Espelage L, Kotzka J, Sill S, Kurowski A, Kim D, Karpinski S, Schnurr TM, Hansen T, Hartwig S, Lehr S, Cames S, Brüning J, Lienhard M, Herwig R, Börno S, Timmermann B, Al-Hasani H, Chadt A. Springer C, et al. Diabetes. 2024 Apr 12:db230463. doi: 10.2337/db23-0463. Online ahead of print. Diabetes. 2024. PMID: 38608276
226 results