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HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. Steuernagel L, et al. Among authors: bruning jc. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20. Nat Metab. 2022. PMID: 36266547 Free PMC article.
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. Quiñones M, et al. Among authors: bruning jc. Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6. Nat Commun. 2018. PMID: 30143607 Free PMC article.
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Wang L, et al. Among authors: bruning jc. JCI Insight. 2019 Feb 7;4(3):e123337. doi: 10.1172/jci.insight.123337. JCI Insight. 2019. PMID: 30728336 Free PMC article.
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding.
Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC. Jais A, et al. Among authors: bruning jc. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16. Neuron. 2020. PMID: 32302532 Free PMC article.
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC. Jiang H, et al. Among authors: bruning jc. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13. Neuron. 2020. PMID: 32407670 Free PMC article.
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function.
Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC. Timper K, et al. Among authors: bruning jc. Cell Metab. 2020 Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001. Epub 2020 May 19. Cell Metab. 2020. PMID: 32433922 Free PMC article.
Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer.
Ostermann AL, Wunderlich CM, Schneiders L, Vogt MC, Woeste MA, Belgardt BF, Niessen CM, Martiny B, Schauss AC, Frommolt P, Nikolaev A, Hövelmeyer N, Sears RC, Koch PJ, Günzel D, Brüning JC, Wunderlich FT. Ostermann AL, et al. Among authors: bruning jc. Nat Metab. 2019 Mar;1(3):371-389. doi: 10.1038/s42255-019-0037-8. Epub 2019 Mar 4. Nat Metab. 2019. PMID: 32694718
241 results