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Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases.
ACS Infect Dis. 2018 Mar 9;4(3):360-372. doi: 10.1021/acsinfecdis.7b00129. Epub 2017 Dec 12.
ACS Infect Dis. 2018.
PMID: 29172434
From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.
Buscató E, Büttner D, Brüggerhoff A, Klingler FM, Weber J, Scholz B, Zivković A, Marschalek R, Stark H, Steinhilber D, Bode HB, Proschak E.
Buscató E, et al. Among authors: bruggerhoff a.
ChemMedChem. 2013 Jun;8(6):919-23. doi: 10.1002/cmdc.201300057. Epub 2013 Apr 17.
ChemMedChem. 2013.
PMID: 23596124
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Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.
Rödl CB, Vogt D, Kretschmer SB, Ihlefeld K, Barzen S, Brüggerhoff A, Achenbach J, Proschak E, Steinhilber D, Stark H, Hofmann B.
Rödl CB, et al. Among authors: bruggerhoff a.
Eur J Med Chem. 2014 Sep 12;84:302-11. doi: 10.1016/j.ejmech.2014.07.025. Epub 2014 Jul 9.
Eur J Med Chem. 2014.
PMID: 25036790
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N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
Blöcher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Brüggerhoff A, Boß M, Kaiser A, Schader T, Göbel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brüne B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E.
Blöcher R, et al. Among authors: bruggerhoff a.
J Med Chem. 2016 Jan 14;59(1):61-81. doi: 10.1021/acs.jmedchem.5b01239. Epub 2015 Dec 25.
J Med Chem. 2016.
PMID: 26595749
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Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.
Buscató El, Wisniewska JM, Rödl CB, Brüggerhoff A, Kaiser A, Rörsch F, Kostewicz E, Wurglics M, Schubert-Zsilavecz M, Grösch S, Steinhilber D, Hofmann B, Proschak E.
Buscató El, et al. Among authors: bruggerhoff a.
Future Med Chem. 2013 May;5(8):865-80. doi: 10.4155/fmc.13.72.
Future Med Chem. 2013.
PMID: 23682565
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Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.
Vogt D, Weber J, Ihlefeld K, Brüggerhoff A, Proschak E, Stark H.
Vogt D, et al. Among authors: bruggerhoff a.
Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. doi: 10.1016/j.bmc.2014.07.044. Epub 2014 Aug 6.
Bioorg Med Chem. 2014.
PMID: 25150091
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