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Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules.
Mendes SS, Marques J, Mesterházy E, Straetener J, Arts M, Pissarro T, Reginold J, Berscheid A, Bornikoel J, Kluj RM, Mayer C, Oesterhelt F, Friães S, Royo B, Schneider T, Brötz-Oesterhelt H, Romão CC, Saraiva LM. Mendes SS, et al. ACS Bio Med Chem Au. 2022 Aug 17;2(4):419-436. doi: 10.1021/acsbiomedchemau.2c00007. Epub 2022 Apr 8. ACS Bio Med Chem Au. 2022. PMID: 35996473 Free PMC article.
Human commensals producing a novel antibiotic impair pathogen colonization.
Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B. Zipperer A, et al. Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634. Nature. 2016. PMID: 27466123
Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition.
Schüller A, Matzner D, Lünse CE, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G, Mayer G. Schüller A, et al. Chembiochem. 2017 Mar 2;18(5):435-440. doi: 10.1002/cbic.201600491. Epub 2017 Jan 30. Chembiochem. 2017. PMID: 28012261
Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. Mokhlesi A, et al. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. J Nat Prod. 2017. PMID: 29094598
Rhodomyrtone (Rom) is a membrane-active compound.
Saising J, Nguyen MT, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schäkermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. Saising J, et al. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1114-1124. doi: 10.1016/j.bbamem.2018.01.011. Epub 2018 Jan 6. Biochim Biophys Acta Biomembr. 2018. PMID: 29317198 Free article.
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.
Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S. Schilling NA, et al. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27. Angew Chem Int Ed Engl. 2019. PMID: 31059155 Free PMC article.
81 results