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Comparison of Proteomic Responses as Global Approach to Antibiotic Mechanism of Action Elucidation.
Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller RG, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE. Senges CHR, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01373-20. doi: 10.1128/AAC.01373-20. Print 2020 Dec 16. Antimicrob Agents Chemother. 2020. PMID: 33046497 Free PMC article.
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H. Brötz-Oesterhelt H, et al. Nat Med. 2005 Oct;11(10):1082-7. doi: 10.1038/nm1306. Epub 2005 Oct 2. Nat Med. 2005. PMID: 16200071
Small cationic antimicrobial peptides delocalize peripheral membrane proteins.
Wenzel M, Chiriac AI, Otto A, Zweytick D, May C, Schumacher C, Gust R, Albada HB, Penkova M, Krämer U, Erdmann R, Metzler-Nolte N, Straus SK, Bremer E, Becher D, Brötz-Oesterhelt H, Sahl HG, Bandow JE. Wenzel M, et al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1409-18. doi: 10.1073/pnas.1319900111. Epub 2014 Mar 24. Proc Natl Acad Sci U S A. 2014. PMID: 24706874 Free PMC article.
Rhodomyrtone (Rom) is a membrane-active compound.
Saising J, Nguyen MT, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schäkermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. Saising J, et al. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1114-1124. doi: 10.1016/j.bbamem.2018.01.011. Epub 2018 Jan 6. Biochim Biophys Acta Biomembr. 2018. PMID: 29317198 Free article.
The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes.
Hörömpöli D, Ciglia C, Glüsenkamp KH, Haustedt LO, Falkenstein-Paul H, Bendas G, Berscheid A, Brötz-Oesterhelt H. Hörömpöli D, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e00986-20. doi: 10.1128/AAC.00986-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468467 Free PMC article.
How many modes of action should an antibiotic have?
Brötz-Oesterhelt H, Brunner NA. Brötz-Oesterhelt H, et al. Curr Opin Pharmacol. 2008 Oct;8(5):564-73. doi: 10.1016/j.coph.2008.06.008. Epub 2008 Jul 30. Curr Opin Pharmacol. 2008. PMID: 18621146 Review.
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