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Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.
Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, Gajewiak J, Salcedo PF, Watkins M, Taylor D, Resager W, Ueberheide B, Bräuner-Osborne H, Whitby FG, Hill CP, Martin LF, Patwardhan A, Concepcion GP, Olivera BM, Safavi-Hemami H. Ramiro IBL, et al. Sci Adv. 2022 Mar 25;8(12):eabk1410. doi: 10.1126/sciadv.abk1410. Epub 2022 Mar 23. Sci Adv. 2022. PMID: 35319982 Free PMC article.
Mutational Landscape of the Proglucagon-Derived Peptides.
Lindquist P, Madsen JS, Bräuner-Osborne H, Rosenkilde MM, Hauser AS. Lindquist P, et al. Front Endocrinol (Lausanne). 2021 Jun 17;12:698511. doi: 10.3389/fendo.2021.698511. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220721 Free PMC article.
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.
van der Velden WJC, Smit FX, Christiansen CB, Møller TC, Hjortø GM, Larsen O, Schiellerup SP, Bräuner-Osborne H, Holst JJ, Hartmann B, Frimurer TM, Rosenkilde MM. van der Velden WJC, et al. ACS Pharmacol Transl Sci. 2021 Jan 19;4(1):296-313. doi: 10.1021/acsptsci.0c00193. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615180 Free PMC article.
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Gabe MBN, et al. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):122-132. doi: 10.1111/bcpt.13289. Epub 2019 Aug 19. Basic Clin Pharmacol Toxicol. 2020. PMID: 31299132 Free PMC article.
G protein-coupled receptor pharmacology-The next generation.
Bräuner-Osborne H, Rosenkilde MM, Gether U, Gloriam DE. Bräuner-Osborne H, et al. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6:3-4. doi: 10.1111/bcpt.13291. Epub 2019 Aug 21. Basic Clin Pharmacol Toxicol. 2020. PMID: 31301209 Free article. No abstract available.
219 results