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Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.
Völker LA, Kaufeld J, Miesbach W, Brähler S, Reinhardt M, Kühne L, Mühlfeld A, Schreiber A, Gaedeke J, Tölle M, Jabs WJ, Özcan F, Markau S, Girndt M, Bauer F, Westhoff TH, Felten H, Hausberg M, Brand M, Gerth J, Bieringer M, Bommer M, Zschiedrich S, Schneider J, Elitok S, Gawlik A, Gäckler A, Kribben A, Schwenger V, Schoenermarck U, Roeder M, Radermacher J, Bramstedt J, Morgner A, Herbst R, Harth A, Potthoff SA, von Auer C, Wendt R, Christ H, Brinkkoetter PT, Menne J. Völker LA, et al. Among authors: brahler s. Blood Adv. 2020 Jul 14;4(13):3085-3092. doi: 10.1182/bloodadvances.2020001973. Blood Adv. 2020. PMID: 32634236 Free PMC article.
The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.
Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter PT. Brähler S, et al. Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F617-26. doi: 10.1152/ajprenal.00059.2015. Epub 2015 Aug 12. Am J Physiol Renal Physiol. 2015. PMID: 26268269 Free article.
As previously published, genetic inhibition of the NF-kappaB essential modulator (NEMO) in podocytes does not affect glomerular function under physiological, nonstressed conditions nor does it alter the initial podocyte response in an experimental glomerulonephritis (NTN) model ( …
As previously published, genetic inhibition of the NF-kappaB essential modulator (NEMO) in podocytes does not affect glomerular function und …
ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP.
Völker LA, Kaufeld J, Miesbach W, Brähler S, Reinhardt M, Kühne L, Mühlfeld A, Schreiber A, Gaedeke J, Tölle M, Jabs WJ, Özcan F, Markau S, Girndt M, Bauer F, Westhoff TH, Felten H, Hausberg M, Brand M, Gerth J, Bieringer M, Bommer M, Zschiedrich S, Schneider J, Elitok S, Gawlik A, Gäckler A, Kribben A, Schwenger V, Schoenermarck U, Roeder M, Radermacher J, Bramstedt J, Morgner A, Herbst R, Harth A, Potthoff SA, von Auer C, Wendt R, Christ H, Brinkkoetter PT, Menne J. Völker LA, et al. Among authors: brahler s. Blood Adv. 2020 Jul 14;4(13):3093-3101. doi: 10.1182/bloodadvances.2020001987. Blood Adv. 2020. PMID: 32634237 Free PMC article.
Personalized, interdisciplinary patient pathway for cross-sector care of multimorbid patients (eliPfad trial): study protocol for a randomized controlled trial.
Lindemann CH, Burst V, Völker LA, Brähler S, Simic D, Becker I, Hellmich M, Kurscheid C, Scholten N, Krauspe R, Leibel K, Stock S, Brinkkoetter PT. Lindemann CH, et al. Among authors: brahler s. Trials. 2024 Mar 11;25(1):177. doi: 10.1186/s13063-024-08026-8. Trials. 2024. PMID: 38468319 Free PMC article.
Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.
Brähler S, Ising C, Hagmann H, Rasmus M, Hoehne M, Kurschat C, Kisner T, Goebel H, Shankland S, Addicks K, Thaiss F, Schermer B, Pasparakis M, Benzing T, Brinkkoetter PT. Brähler S, et al. Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1473-85. doi: 10.1152/ajprenal.00031.2012. Epub 2012 Sep 12. Am J Physiol Renal Physiol. 2012. PMID: 22975019 Free article.
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.
Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Ising C, et al. Among authors: brahler s. EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916. EMBO Mol Med. 2015. PMID: 25643582 Free PMC article.
24 results