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In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06.
Reis PA, Pais KC, Pereira MF, Douradinha B, Costa NF, Kaiser CR, Bozza PT, Areas ALL, Zalis MG, de Lima Ferreira M, de Souza MVN, da Silva Frutuoso V, de Castro-Faria-Neto HC. Reis PA, et al. Among authors: bozza pt. Parasitol Res. 2018 Nov;117(11):3585-3590. doi: 10.1007/s00436-018-6057-6. Epub 2018 Aug 25. Parasitol Res. 2018. PMID: 30145706
Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes.
de Assis EF, Silva AR, Caiado LF, Marathe GK, Zimmerman GA, Prescott SM, McIntyre TM, Bozza PT, de Castro-Faria-Neto HC. de Assis EF, et al. Among authors: bozza pt. J Immunol. 2003 Aug 15;171(4):2090-8. doi: 10.4049/jimmunol.171.4.2090. J Immunol. 2003. PMID: 12902515
Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy.
Reis PA, Comim CM, Hermani F, Silva B, Barichello T, Portella AC, Gomes FC, Sab IM, Frutuoso VS, Oliveira MF, Bozza PT, Bozza FA, Dal-Pizzol F, Zimmerman GA, Quevedo J, Castro-Faria-Neto HC. Reis PA, et al. Among authors: bozza pt, bozza fa. PLoS Pathog. 2010 Jun 24;6(6):e1000963. doi: 10.1371/journal.ppat.1000963. PLoS Pathog. 2010. PMID: 20585569 Free PMC article.
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria.
Reis PA, Estato V, da Silva TI, d'Avila JC, Siqueira LD, Assis EF, Bozza PT, Bozza FA, Tibiriça EV, Zimmerman GA, Castro-Faria-Neto HC. Reis PA, et al. Among authors: bozza pt, bozza fa. PLoS Pathog. 2012 Dec;8(12):e1003099. doi: 10.1371/journal.ppat.1003099. Epub 2012 Dec 27. PLoS Pathog. 2012. PMID: 23300448 Free PMC article.
Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production.
Gonçalves-de-Albuquerque CF, Burth P, Silva AR, de Moraes IM, de Jesus Oliveira FM, Santelli RE, Freire AS, Bozza PT, Younes-Ibrahim M, de Castro-Faria-Neto HC, de Castro-Faria MV. Gonçalves-de-Albuquerque CF, et al. Among authors: bozza pt. J Inflamm (Lond). 2013 Oct 31;10(1):34. doi: 10.1186/1476-9255-10-34. J Inflamm (Lond). 2013. PMID: 24175969 Free PMC article.
N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity.
Barbosa-Lima G, da Silveira Pinto LS, Kaiser CR, Wardell JL, De Freitas CS, Vieira YR, Marttorelli A, Cerbino Neto J, Bozza PT, Wardell SMSV, de Souza MVN, Souza TML. Barbosa-Lima G, et al. Among authors: bozza pt. Eur J Med Chem. 2017 Feb 15;127:434-441. doi: 10.1016/j.ejmech.2017.01.007. Epub 2017 Jan 6. Eur J Med Chem. 2017. PMID: 28092859
Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae.
Ferreira AC, Zaverucha-do-Valle C, Reis PA, Barbosa-Lima G, Vieira YR, Mattos M, Silva PP, Sacramento C, de Castro Faria Neto HC, Campanati L, Tanuri A, Brüning K, Bozza FA, Bozza PT, Souza TML. Ferreira AC, et al. Among authors: bozza pt, bozza fa. Sci Rep. 2017 Aug 25;7(1):9409. doi: 10.1038/s41598-017-09797-8. Sci Rep. 2017. PMID: 28842610 Free PMC article.
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Ferreira AC, Reis PA, de Freitas CS, Sacramento CQ, Villas Bôas Hoelz L, Bastos MM, Mattos M, Rocha N, Gomes de Azevedo Quintanilha I, da Silva Gouveia Pedrosa C, Rocha Quintino Souza L, Correia Loiola E, Trindade P, Rangel Vieira Y, Barbosa-Lima G, de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML. Ferreira AC, et al. Among authors: bozza pt, bozza fa. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01389-18. doi: 10.1128/AAC.01389-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30455237 Free PMC article.
Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.
Medeiros-de-Moraes IM, Gonçalves-de-Albuquerque CF, Kurz ARM, Oliveira FMJ, de Abreu VHP, Torres RC, Carvalho VF, Estato V, Bozza PT, Sperandio M, de Castro-Faria-Neto HC, Silva AR. Medeiros-de-Moraes IM, et al. Among authors: bozza pt. Oxid Med Cell Longev. 2018 Nov 13;2018:6053492. doi: 10.1155/2018/6053492. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30538802 Free PMC article.
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo.
de Freitas CS, Higa LM, Sacramento CQ, Ferreira AC, Reis PA, Delvecchio R, Monteiro FL, Barbosa-Lima G, James Westgarth H, Vieira YR, Mattos M, Rocha N, Hoelz LVB, Leme RPP, Bastos MM, Rodrigues GOL, Lopes CEM, Queiroz-Junior CM, Lima CX, Costa VV, Teixeira MM, Bozza FA, Bozza PT, Boechat N, Tanuri A, Souza TML. de Freitas CS, et al. Among authors: bozza pt, bozza fa. PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30699122 Free PMC article.
320 results