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Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress.
Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, Decsesznak J, Chu HW, Bratton DL, Riches DW, Bowler RP. Tollefson AK, et al. Among authors: bowler rp. Free Radic Biol Med. 2010 Dec 15;49(12):1937-46. doi: 10.1016/j.freeradbiomed.2010.09.022. Epub 2010 Sep 29. Free Radic Biol Med. 2010. PMID: 20887783 Free PMC article.
Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Villegas LR, et al. Among authors: bowler rp. Antioxid Redox Signal. 2013 May 10;18(14):1753-64. doi: 10.1089/ars.2012.4799. Epub 2013 Feb 5. Antioxid Redox Signal. 2013. PMID: 23240585 Free PMC article.
A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution.
Hartney JM, Stidham T, Goldstrohm DA, Oberley-Deegan RE, Weaver MR, Valnickova-Hansen Z, Scavenius C, Benninger RK, Leahy KF, Johnson R, Gally F, Kosmider B, Zimmermann AK, Enghild JJ, Nozik-Grayck E, Bowler RP. Hartney JM, et al. Among authors: bowler rp. Circ Cardiovasc Genet. 2014 Oct;7(5):659-66. doi: 10.1161/CIRCGENETICS.113.000504. Epub 2014 Aug 1. Circ Cardiovasc Genet. 2014. PMID: 25085920 Free PMC article.
The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues.
Pate KM, Sherk VD, Carpenter RD, Weaver M, Crapo S, Gally F, Chatham LS, Goldstrohm DA, Crapo JD, Kohrt WM, Bowler RP, Oberley-Deegan RE, Regan EA. Pate KM, et al. Among authors: bowler rp. J Appl Physiol (1985). 2015 Mar 15;118(6):760-7. doi: 10.1152/japplphysiol.00112.2014. Epub 2015 Jan 15. J Appl Physiol (1985). 2015. PMID: 25593283 Free PMC article.
The R213G polymorphism in SOD3 protects against allergic airway inflammation.
Gaurav R, Varasteh JT, Weaver MR, Jacobson SR, Hernandez-Lagunas L, Liu Q, Nozik-Grayck E, Chu HW, Alam R, Nordestgaard BG, Kobylecki CJ, Afzal S, Chupp GL, Bowler RP. Gaurav R, et al. Among authors: bowler rp. JCI Insight. 2017 Sep 7;2(17):e95072. doi: 10.1172/jci.insight.95072. eCollection 2017 Sep 7. JCI Insight. 2017. PMID: 28878123 Free PMC article.
310 results