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Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.
Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Barnett BP, et al. Among authors: bowers em. Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. Epub 2010 Nov 18. Science. 2010. PMID: 21097901 Free PMC article.
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn YH, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Dancy BM, et al. Among authors: bowers em. Chembiochem. 2012 Sep 24;13(14):2113-21. doi: 10.1002/cbic.201200381. Epub 2012 Sep 7. Chembiochem. 2012. PMID: 22961914 Free PMC article.
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA. Bowers EM, et al. Chem Biol. 2010 May 28;17(5):471-82. doi: 10.1016/j.chembiol.2010.03.006. Chem Biol. 2010. PMID: 20534345 Free PMC article.
De novo discovery of serotonin N-acetyltransferase inhibitors.
Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. Szewczuk LM, et al. Among authors: bowers em. J Med Chem. 2007 Nov 1;50(22):5330-8. doi: 10.1021/jm0706463. Epub 2007 Oct 9. J Med Chem. 2007. PMID: 17924613 Free PMC article.
Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells.
Yan G, Eller MS, Elm C, Larocca CA, Ryu B, Panova IP, Dancy BM, Bowers EM, Meyers D, Lareau L, Cole PA, Taverna SD, Alani RM. Yan G, et al. Among authors: bowers em. J Invest Dermatol. 2013 Oct;133(10):2444-2452. doi: 10.1038/jid.2013.187. Epub 2013 Apr 18. J Invest Dermatol. 2013. PMID: 23698071 Free PMC article.
27 results