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Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W. Gruszczyk J, et al. Among authors: bourguet w. Nat Commun. 2022 Nov 16;13(1):7010. doi: 10.1038/s41467-022-34773-w. Nat Commun. 2022. PMID: 36385050 Free PMC article.
Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Pérez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W. Pogenberg V, et al. Among authors: bourguet w. J Biol Chem. 2005 Jan 14;280(2):1625-33. doi: 10.1074/jbc.M409302200. Epub 2004 Nov 4. J Biol Chem. 2005. PMID: 15528208 Free article.
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum V, Pérez E, Germain P, Rodríguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W. Nahoum V, et al. Among authors: bourguet w. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17323-8. doi: 10.1073/pnas.0705356104. Epub 2007 Oct 18. Proc Natl Acad Sci U S A. 2007. PMID: 17947383 Free PMC article.
N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.
Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A. Benod C, et al. Among authors: bourguet w. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18304819
Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.
Nahoum V, Lipski A, Quillard F, Guichou JF, Boublik Y, Pérez E, Germain P, de Lera AR, Bourguet W. Nahoum V, et al. Among authors: bourguet w. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):614-6. doi: 10.1107/S1744309108015492. Epub 2008 Jun 11. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18607089 Free PMC article.
101 results