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Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.
Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Bouley R, et al. J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2. J Am Chem Soc. 2015. PMID: 25629446 Free PMC article.
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.
Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CA, Mobashery S, Chang M, Dantas G. Gonzales PR, et al. Among authors: bouley r. Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14. Nat Chem Biol. 2015. PMID: 26368589 Free PMC article.
Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.
Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Bouley R, et al. J Med Chem. 2016 May 26;59(10):5011-21. doi: 10.1021/acs.jmedchem.6b00372. Epub 2016 May 5. J Med Chem. 2016. PMID: 27088777 Free PMC article.
The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.
Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. Janardhanan J, et al. Among authors: bouley r. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30858202 Free PMC article.
Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery.
Martínez-Caballero S, Mahasenan KV, Kim C, Molina R, Feltzer R, Lee M, Bouley R, Hesek D, Fisher JF, Muñoz IG, Chang M, Mobashery S, Hermoso JA. Martínez-Caballero S, et al. Among authors: bouley r. Comput Struct Biotechnol J. 2021 Sep 17;19:5392-5405. doi: 10.1016/j.csbj.2021.09.018. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34667534 Free PMC article.
82 results