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Superoxide Dismutase 2 is dispensable for platelet function.
Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. Fidler TP, et al. Among authors: boudreau lh. Thromb Haemost. 2017 Oct 5;117(10):1859-1867. doi: 10.1160/TH17-03-0174. Epub 2017 Aug 3. Thromb Haemost. 2017. PMID: 28771279 Free PMC article.
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.
Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, Hamzeh-Cognasse H, Cognasse F, Garraud O, Nigrovic PA, Guderley H, Lacroix S, Thibault L, Semple JW, Gelb MH, Boilard E. Boudreau LH, et al. Blood. 2014 Oct 2;124(14):2173-83. doi: 10.1182/blood-2014-05-573543. Epub 2014 Jul 31. Blood. 2014. PMID: 25082876 Free PMC article.
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E. Duchez AC, et al. Among authors: boudreau lh. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73. doi: 10.1073/pnas.1507905112. Epub 2015 Jun 23. Proc Natl Acad Sci U S A. 2015. PMID: 26106157 Free PMC article.
Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.
Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. Fidler TP, et al. Among authors: boudreau lh. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1628-1639. doi: 10.1161/ATVBAHA.117.309184. Epub 2017 Jun 29. Arterioscler Thromb Vasc Biol. 2017. PMID: 28663252 Free PMC article.
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.
Cloutier N, Tan S, Boudreau LH, Cramb C, Subbaiah R, Lahey L, Albert A, Shnayder R, Gobezie R, Nigrovic PA, Farndale RW, Robinson WH, Brisson A, Lee DM, Boilard E. Cloutier N, et al. Among authors: boudreau lh. EMBO Mol Med. 2013 Feb;5(2):235-49. doi: 10.1002/emmm.201201846. Epub 2012 Dec 11. EMBO Mol Med. 2013. PMID: 23165896 Free PMC article.
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