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Investigative safety science as a competitive advantage for Pharma.
Moggs J, Moulin P, Pognan F, Brees D, Leonard M, Busch S, Cordier A, Heard DJ, Kammüller M, Merz M, Bouchard P, Chibout SD. Moggs J, et al. Among authors: bouchard p. Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1071-82. doi: 10.1517/17425255.2012.693914. Epub 2012 Jul 7. Expert Opin Drug Metab Toxicol. 2012. PMID: 22769724 Review.
Safety differentiation: emerging competitive edge in drug development.
Uteng M, Urban L, Brees D, Muller PY, Kullak-Ublick GA, Bouchard P, Tougas G, Chibout SD. Uteng M, et al. Among authors: bouchard p. Drug Discov Today. 2019 Jan;24(1):285-292. doi: 10.1016/j.drudis.2018.09.009. Epub 2018 Sep 19. Drug Discov Today. 2019. PMID: 30244081 Free article. Review.
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.
Pognan F, Mahl JA, Papoutsi M, Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek-Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout SD, Bouchard P, Trendelenburg C. Pognan F, et al. Among authors: bouchard p. Arch Toxicol. 2018 May;92(5):1877-1891. doi: 10.1007/s00204-018-2189-9. Epub 2018 Mar 19. Arch Toxicol. 2018. PMID: 29556671 Free PMC article.
Discovery and development of therapeutic aptamers.
Bouchard PR, Hutabarat RM, Thompson KM. Bouchard PR, et al. Annu Rev Pharmacol Toxicol. 2010;50:237-57. doi: 10.1146/annurev.pharmtox.010909.105547. Annu Rev Pharmacol Toxicol. 2010. PMID: 20055704 Review.
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome.
Baedorf-Kassis E, Murn M, Dzierba AL, Serra AL, Garcia I, Minus E, Padilla C, Sarge T, Goodspeed VM, Matthay MA, Gong MN, Cook D, Loring SH, Talmor D, Beitler JR; EPVent-2 Study Group. Baedorf-Kassis E, et al. Crit Care. 2024 Apr 23;28(1):136. doi: 10.1186/s13054-024-04920-4. Crit Care. 2024. PMID: 38654391 Free PMC article.
591 results