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Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells.
FASEB J. 2019 Jul;33(7):8468-8478. doi: 10.1096/fj.201802467R. Epub 2019 Apr 23.
FASEB J. 2019.
PMID: 31013438
Free PMC article.
Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.
Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA.
Saban DR, et al. Among authors: botten n.
Mucosal Immunol. 2019 Jan;12(1):145-153. doi: 10.1038/s41385-018-0089-1. Epub 2018 Oct 2.
Mucosal Immunol. 2019.
PMID: 30279513
Free PMC article.
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Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells.
Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP, Serhan CN, Dartt DA.
Kaye R, et al. Among authors: botten n.
Exp Eye Res. 2019 Mar;180:53-62. doi: 10.1016/j.exer.2018.11.018. Epub 2018 Dec 1.
Exp Eye Res. 2019.
PMID: 30513286
Free PMC article.
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Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells.
Yang M, Botten N, Hodges R, Bair J, Utheim TP, Serhan CN, Dartt DA.
Yang M, et al. Among authors: botten n.
Int J Mol Sci. 2021 Dec 23;23(1):141. doi: 10.3390/ijms23010141.
Int J Mol Sci. 2021.
PMID: 35008563
Free PMC article.
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Resolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells.
Botten N, Hodges RR, Bair J, Utheim TP, Serhan CN, Yang M, Dartt DA.
Botten N, et al.
J Cell Physiol. 2022 Oct;237(10):3816-3833. doi: 10.1002/jcp.30854. Epub 2022 Sep 6.
J Cell Physiol. 2022.
PMID: 36066128
Free PMC article.
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