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A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. Fu J, et al. Among authors: bottegoni g. Nat Neurosci. 2011 Nov 20;15(1):64-9. doi: 10.1038/nn.2986. Nat Neurosci. 2011. PMID: 22101642 Free PMC article.
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
De Simone A, Russo D, Ruda GF, Micoli A, Ferraro M, Di Martino RM, Ottonello G, Summa M, Armirotti A, Bandiera T, Cavalli A, Bottegoni G. De Simone A, et al. Among authors: bottegoni g. J Med Chem. 2017 Mar 23;60(6):2287-2304. doi: 10.1021/acs.jmedchem.6b01578. Epub 2017 Mar 2. J Med Chem. 2017. PMID: 28182408
Dopamine D3 receptor ligands: a patent review (2014-2020).
Di Martino RMC, Cavalli A, Bottegoni G. Di Martino RMC, et al. Among authors: bottegoni g. Expert Opin Ther Pat. 2022 Jun;32(6):605-627. doi: 10.1080/13543776.2022.2049240. Epub 2022 Mar 24. Expert Opin Ther Pat. 2022. PMID: 35235753 Review.
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.
Basagni F, Ortega JA, Bertozzi SM, Armirotti A, Summa M, Bertorelli R, Bartolini M, Mellor IR, Bedeschi M, Bottegoni G, Lembo V, Minarini A, Cavalli A, Rosini M. Basagni F, et al. Among authors: bottegoni g. Eur J Med Chem. 2023 Dec 5;261:115803. doi: 10.1016/j.ejmech.2023.115803. Epub 2023 Sep 12. Eur J Med Chem. 2023. PMID: 37734258 Free article.
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration.
Di Fruscia P, Carbone A, Bottegoni G, Berti F, Giacomina F, Ponzano S, Pagliuca C, Fiasella A, Pizzirani D, Ortega JA, Nuzzi A, Tarozzo G, Mengatto L, Giampà R, Penna I, Russo D, Romeo E, Summa M, Bertorelli R, Armirotti A, Bertozzi SM, Reggiani A, Bandiera T, Bertozzi F. Di Fruscia P, et al. Among authors: bottegoni g. J Med Chem. 2021 Sep 23;64(18):13327-13355. doi: 10.1021/acs.jmedchem.1c00575. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34469137 Free PMC article.
67 results