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A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
Fallacara AL, Zamperini C, Podolski-Renić A, Dinić J, Stanković T, Stepanović M, Mancini A, Rango E, Iovenitti G, Molinari A, Bugli F, Sanguinetti M, Torelli R, Martini M, Maccari L, Valoti M, Dreassi E, Botta M, Pešić M, Schenone S. Fallacara AL, et al. Among authors: botta m. Cancers (Basel). 2019 Jun 19;11(6):848. doi: 10.3390/cancers11060848. Cancers (Basel). 2019. PMID: 31248184 Free PMC article.
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
Tintori C, Fallacara AL, Radi M, Zamperini C, Dreassi E, Crespan E, Maga G, Schenone S, Musumeci F, Brullo C, Richters A, Gasparrini F, Angelucci A, Festuccia C, Delle Monache S, Rauh D, Botta M. Tintori C, et al. Among authors: botta m. J Med Chem. 2015 Jan 8;58(1):347-61. doi: 10.1021/jm5013159. Epub 2014 Dec 3. J Med Chem. 2015. PMID: 25469771
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.
Vignaroli G, Iovenitti G, Zamperini C, Coniglio F, Calandro P, Molinari A, Fallacara AL, Sartucci A, Calgani A, Colecchia D, Mancini A, Festuccia C, Dreassi E, Valoti M, Musumeci F, Chiariello M, Angelucci A, Botta M, Schenone S. Vignaroli G, et al. Among authors: botta m. J Med Chem. 2017 Jul 27;60(14):6305-6320. doi: 10.1021/acs.jmedchem.7b00637. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28650650
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.
Fallacara AL, Mancini A, Zamperini C, Dreassi E, Marianelli S, Chiariello M, Pozzi G, Santoro F, Botta M, Schenone S. Fallacara AL, et al. Among authors: botta m. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3196-3200. doi: 10.1016/j.bmcl.2017.05.015. Epub 2017 May 17. Bioorg Med Chem Lett. 2017. PMID: 28558969
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
Molinari A, Fallacara AL, Di Maria S, Zamperini C, Poggialini F, Musumeci F, Schenone S, Angelucci A, Colapietro A, Crespan E, Kissova M, Maga G, Botta M. Molinari A, et al. Among authors: botta m. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3454-3457. doi: 10.1016/j.bmcl.2018.09.024. Epub 2018 Sep 20. Bioorg Med Chem Lett. 2018. PMID: 30262428
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Orofino F, Truglio GI, Fiorucci D, D'Agostino I, Borgini M, Poggialini F, Zamperini C, Dreassi E, Maccari L, Torelli R, Martini C, Bernabei M, Meis JF, Khandelwal NK, Prasad R, Sanguinetti M, Bugli F, Botta M. Orofino F, et al. Among authors: botta m. Int J Antimicrob Agents. 2020 Mar;55(3):105865. doi: 10.1016/j.ijantimicag.2019.105865. Epub 2019 Dec 20. Int J Antimicrob Agents. 2020. PMID: 31866465
AuNP Pyrazolo[3,4-d]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma.
Molinari A, Iovenitti G, Mancini A, Gravina GL, Chebbi M, Caruana M, Vignaroli G, Orofino F, Rango E, Angelucci A, Dreassi E, Schenone S, Botta M. Molinari A, et al. Among authors: botta m. ACS Med Chem Lett. 2020 Mar 5;11(5):664-670. doi: 10.1021/acsmedchemlett.9b00538. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435368 Free PMC article.
722 results