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Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms.
Botschuijver S, van Diest SA, van Thiel IAM, Saia RS, Strik AS, Yu Z, Maria-Ferreira D, Welting O, Keszthelyi D, Jennings G, Heinsbroek SEM, Elferink RPO, Schuren FHJ, de Jonge WJ, van den Wijngaard RM. Botschuijver S, et al. Sci Rep. 2019 Aug 29;9(1):12530. doi: 10.1038/s41598-019-49096-y. Sci Rep. 2019. PMID: 31467355 Free PMC article.
Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.
Botschuijver S, Welting O, Levin E, Maria-Ferreira D, Koch E, Montijn RC, Seppen J, Hakvoort TBM, Schuren FHJ, de Jonge WJ, van den Wijngaard RM. Botschuijver S, et al. Neurogastroenterol Motil. 2018 Jun;30(6):e13299. doi: 10.1111/nmo.13299. Epub 2018 Jan 31. Neurogastroenterol Motil. 2018. PMID: 29383802
Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM. Botschuijver S, et al. Gastroenterology. 2017 Oct;153(4):1026-1039. doi: 10.1053/j.gastro.2017.06.004. Epub 2017 Jun 15. Gastroenterology. 2017. PMID: 28624575
Painful interactions: Microbial compounds and visceral pain.
van Thiel IAM, Botschuijver S, de Jonge WJ, Seppen J. van Thiel IAM, et al. Among authors: botschuijver s. Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165534. doi: 10.1016/j.bbadis.2019.165534. Epub 2019 Oct 18. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31634534 Free article. Review.