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Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
Lenting K, Khurshed M, Peeters TH, van den Heuvel CNAM, van Lith SAM, de Bitter T, Hendriks W, Span PN, Molenaar RJ, Botman D, Verrijp K, Heerschap A, Ter Laan M, Kusters B, van Ewijk A, Huynen MA, van Noorden CJF, Leenders WPJ. Lenting K, et al. Among authors: botman d. FASEB J. 2019 Jan;33(1):557-571. doi: 10.1096/fj.201800907RR. Epub 2018 Jul 12. FASEB J. 2019. PMID: 30001166
Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.
Molenaar RJ, Botman D, Smits MA, Hira VV, van Lith SA, Stap J, Henneman P, Khurshed M, Lenting K, Mul AN, Dimitrakopoulou D, van Drunen CM, Hoebe RA, Radivoyevitch T, Wilmink JW, Maciejewski JP, Vandertop WP, Leenders WP, Bleeker FE, van Noorden CJ. Molenaar RJ, et al. Among authors: botman d. Cancer Res. 2015 Nov 15;75(22):4790-802. doi: 10.1158/0008-5472.CAN-14-3603. Epub 2015 Sep 11. Cancer Res. 2015. PMID: 26363012
A yeast FRET biosensor enlightens cAMP signaling.
Botman D, O'Toole TG, Goedhart J, Bruggeman FJ, van Heerden JH, Teusink B. Botman D, et al. Mol Biol Cell. 2021 Jun 15;32(13):1229-1240. doi: 10.1091/mbc.E20-05-0319. Epub 2021 Apr 21. Mol Biol Cell. 2021. PMID: 33881352 Free PMC article.
Serial propagation in water-in-oil emulsions selects for Saccharomyces cerevisiae strains with a reduced cell size or an increased biomass yield on glucose.
van Tatenhove-Pel RJ, Zwering E, Boreel DF, Falk M, van Heerden JH, Kes MBMJ, Kranenburg CI, Botman D, Teusink B, Bachmann H. van Tatenhove-Pel RJ, et al. Among authors: botman d. Metab Eng. 2021 Mar;64:1-14. doi: 10.1016/j.ymben.2020.12.005. Epub 2021 Jan 5. Metab Eng. 2021. PMID: 33418011 Free article.
Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203.
Chauhan P, van der Meulen SA, Simões Caetano JM, Goojani HG, Botman D, van Spanning R, Lill H, Bald D. Chauhan P, et al. Among authors: botman d. Int J Mol Sci. 2022 Sep 7;23(18):10331. doi: 10.3390/ijms231810331. Int J Mol Sci. 2022. PMID: 36142240 Free PMC article.
15 results