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Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.
Duregon E, Fernandez ME, Martinez Romero J, Di Germanio C, Cabassa M, Voloshchuk R, Ehrlich-Mora MR, Moats JM, Wong S, Bosompra O, Rudderow A, Morrell CH, Camandola S, Price NL, Aon MA, Bernier M, de Cabo R. Duregon E, et al. Among authors: bosompra o. Cell Metab. 2023 Jul 11;35(7):1179-1194.e5. doi: 10.1016/j.cmet.2023.05.003. Cell Metab. 2023. PMID: 37437544
Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition.
Pomatto-Watson LCD, Bodogai M, Bosompra O, Kato J, Wong S, Carpenter M, Duregon E, Chowdhury D, Krishna P, Ng S, Ragonnaud E, Salgado R, Gonzalez Ericsson P, Diaz-Ruiz A, Bernier M, Price NL, Biragyn A, Longo VD, de Cabo R. Pomatto-Watson LCD, et al. Among authors: bosompra o. Nat Commun. 2021 Oct 27;12(1):6201. doi: 10.1038/s41467-021-26431-4. Nat Commun. 2021. PMID: 34707136 Free PMC article.
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer.
Pomatto-Watson LCD, Bodogai M, Carpenter M, Chowdhury D, Krishna P, Ng S, Bosompra O, Kato J, Wong S, Reyes-Sepulveda C, Bernier M, Price NL, Biragyn A, de Cabo R. Pomatto-Watson LCD, et al. Among authors: bosompra o. Geroscience. 2022 Oct;44(5):2471-2490. doi: 10.1007/s11357-022-00635-y. Epub 2022 Aug 23. Geroscience. 2022. PMID: 35996062 Free PMC article.
RECK isoforms have opposing effects on cell migration.
Lee HN, Mitra M, Bosompra O, Corney DC, Johnson EL, Rashed N, Ho LD, Coller HA. Lee HN, et al. Among authors: bosompra o. Mol Biol Cell. 2018 Aug 1;29(15):1825-1838. doi: 10.1091/mbc.E17-12-0708. Epub 2018 Jun 6. Mol Biol Cell. 2018. PMID: 29874120 Free PMC article.