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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice.
Thomas SK, Wattenberg MM, Choi-Bose S, Uhlik M, Harrison B, Coho H, Cassella CR, Stone ML, Patel D, Markowitz K, Delman D, Chisamore M, Drees J, Bose N, Beatty GL. Thomas SK, et al. Among authors: bose n. Nat Commun. 2023 Oct 10;14(1):6330. doi: 10.1038/s41467-023-41771-z. Nat Commun. 2023. PMID: 37816712 Free PMC article.
A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer.
Thomas M, Sadjadian P, Kollmeier J, Lowe J, Mattson P, Trout JR, Gargano M, Patchen ML, Walsh R, Beliveau M, Marier JF, Bose N, Gorden K, Schneller F 3rd. Thomas M, et al. Among authors: bose n. Invest New Drugs. 2017 Jun;35(3):345-358. doi: 10.1007/s10637-017-0450-3. Epub 2017 Mar 16. Invest New Drugs. 2017. PMID: 28303530 Free PMC article. Clinical Trial.
Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1.
Wattenberg MM, Coho H, Herrera VM, Graham K, Stone ML, Xue Y, Chang RB, Cassella C, Liu M, Choi-Bose S, Thomas SK, Choi H, Li Y, Markowitz K, Melendez L, Gianonne M, Bose N, Beatty GL. Wattenberg MM, et al. Among authors: bose n. Sci Immunol. 2023 Nov 17;8(89):eadj5097. doi: 10.1126/sciimmunol.adj5097. Epub 2023 Nov 17. Sci Immunol. 2023. PMID: 37976347 Free PMC article.
Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers.
Bose N, Ottoson NR, Qiu X, Harrison B, Lowe JR, Uhlik MT, Rathmann BT, Kangas TO, Jordan LR, Ertelt KE, Jonas AB, Walsh RM, Chan ASH, Fulton RB, Leonardo SM, Fraser KA, Gorden KB, Matson MA, Graff JR, Huhn RD. Bose N, et al. J Immunol. 2019 May 15;202(10):2945-2956. doi: 10.4049/jimmunol.1801533. Epub 2019 Apr 15. J Immunol. 2019. PMID: 30988115 Clinical Trial.
Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation.
Chan AS, Jonas AB, Qiu X, Ottoson NR, Walsh RM, Gorden KB, Harrison B, Maimonis PJ, Leonardo SM, Ertelt KE, Danielson ME, Michel KS, Nelson M, Graff JR, Patchen ML, Bose N. Chan AS, et al. Among authors: bose n. PLoS One. 2016 Nov 3;11(11):e0165909. doi: 10.1371/journal.pone.0165909. eCollection 2016. PLoS One. 2016. PMID: 27812183 Free PMC article.
160 results