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Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Leal RB, Lopes MW, Formolo DA, de Carvalho CR, Hoeller AA, Latini A, Sousa DS, Wolf P, Prediger RD, Bortolotto ZA, Linhares MN, Lin K, Walz R. Leal RB, et al. Among authors: bortolotto za. Mol Psychiatry. 2020 Mar;25(3):655-665. doi: 10.1038/s41380-018-0084-7. Epub 2018 Jun 7. Mol Psychiatry. 2020. PMID: 29880883
Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.
Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA, Collingridge GL. Lodge D, et al. Among authors: bortolotto za. Neuropharmacology. 2013 Nov;74:135-46. doi: 10.1016/j.neuropharm.2013.03.011. Epub 2013 Mar 26. Neuropharmacology. 2013. PMID: 23542080
A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system.
Lopes MW, Leal RB, Guarnieri R, Schwarzbold ML, Hoeller A, Diaz AP, Boos GL, Lin K, Linhares MN, Nunes JC, Quevedo J, Bortolotto ZA, Markowitsch HJ, Lightman SL, Walz R. Lopes MW, et al. Among authors: bortolotto za. Transl Psychiatry. 2016 Dec 13;6(12):e986. doi: 10.1038/tp.2016.251. Transl Psychiatry. 2016. PMID: 27959333 Free PMC article. Clinical Trial.
The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
de Carvalho CR, Lopes MW, Constantino LC, Hoeller AA, de Melo HM, Guarnieri R, Linhares MN, Bortolotto ZA, Prediger RD, Latini A, Lin K, Licinio J, Leal RB, Walz R. de Carvalho CR, et al. Among authors: bortolotto za. Mol Psychiatry. 2021 Dec;26(12):7257-7269. doi: 10.1038/s41380-021-01203-0. Epub 2021 Jul 27. Mol Psychiatry. 2021. PMID: 34316004
114 results