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Page 1
Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts.
Sperotto NDM, Silva RBM, Perelló MA, Borsoi AF, da Silva Dadda A, Roth CD, Freitas RDS, de Souza APD, Freitas DDN, Picada JN, de Sousa JT, Nabinger DD, Altenhofen S, Bonan CD, Rodrigues-Junior VS, Bizarro CV, Basso LA, Machado P. Sperotto NDM, et al. Among authors: borsoi af. Biomed Pharmacother. 2021 Jul;139:111672. doi: 10.1016/j.biopha.2021.111672. Epub 2021 May 6. Biomed Pharmacother. 2021. PMID: 33965731 Free article.
1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity.
Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, Basso LA, Santos DS, Machado P. Macchi FS, et al. Among authors: borsoi af. Eur J Med Chem. 2018 Jul 15;155:153-164. doi: 10.1016/j.ejmech.2018.06.005. Epub 2018 Jun 2. Eur J Med Chem. 2018. PMID: 29885576
Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA. Paz JD, et al. Among authors: borsoi af. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. doi: 10.1016/j.ejmech.2022.114908. Epub 2022 Nov 18. Eur J Med Chem. 2023. PMID: 36435016
Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments.
Freitas de Freitas T, Roth CD, Abbadi BL, Hopf FSM, Perelló MA, de Matos Czeczot A, de Souza EV, Borsoi AF, Machado P, Bizarro CV, Basso LA, Timmers LFSM. Freitas de Freitas T, et al. Among authors: borsoi af. J Comput Aided Mol Des. 2023 Mar;37(3):117-128. doi: 10.1007/s10822-022-00495-w. Epub 2022 Dec 22. J Comput Aided Mol Des. 2023. PMID: 36547753 Free PMC article.
Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity.
Borsoi AF, Silva Ramos A, Sperotto N, Abbadi BL, Souza Macchi Hopf F, da Silva Dadda A, Scheibler Rambo R, Neves Muniz M, Delgado Paz J, Silveira Grams E, Fries da Silva F, Pissinate K, Galina L, Calle González L, Silva Duarte L, Alberton Perelló M, de Matos Czeczot A, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. ACS Med Chem Lett. 2024 Mar 11;15(4):493-500. doi: 10.1021/acsmedchemlett.3c00570. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628799