Borodkin V - Search Results

1

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor.

Raimi OG, Hurtado-Guerrero R, Borodkin V, Ferenbach A, Urbaniak MD, Ferguson MAJ, van Aalten DMF. Raimi OG, et al. Among authors: borodkin v. RSC Chem Biol. 2020 Mar 24;1(1):13-25. doi: 10.1039/c9cb00017h. eCollection 2020 Apr 16. RSC Chem Biol. 2020. PMID: 34458745 Free PMC article.

2

The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid.

Yashunsky DV, Borodkin VS, Ferguson MA, Nikolaev AV. Yashunsky DV, et al. Among authors: borodkin vs. Angew Chem Int Ed Engl. 2006 Jan 9;45(3):468-74. doi: 10.1002/anie.200502779. Angew Chem Int Ed Engl. 2006. PMID: 16342127 No abstract available.

3

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.

Dorfmueller HC, Borodkin VS, Schimpl M, Shepherd SM, Shpiro NA, van Aalten DM. Dorfmueller HC, et al. J Am Chem Soc. 2006 Dec 27;128(51):16484-5. doi: 10.1021/ja066743n. J Am Chem Soc. 2006. PMID: 17177381 Free PMC article.

4

Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.

Pathak S, Dorfmueller HC, Borodkin VS, van Aalten DM. Pathak S, et al. Chem Biol. 2008 Aug 25;15(8):799-807. doi: 10.1016/j.chembiol.2008.06.010. Chem Biol. 2008. PMID: 18721751 Free PMC article.

5

Structural insights into mechanism and specificity of O-GlcNAc transferase.

Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM. Clarke AJ, et al. Among authors: borodkin v. EMBO J. 2008 Oct 22;27(20):2780-8. doi: 10.1038/emboj.2008.186. Epub 2008 Sep 25. EMBO J. 2008. PMID: 18818698 Free PMC article.

6

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation.

Dorfmueller HC, Borodkin VS, Schimpl M, van Aalten DM. Dorfmueller HC, et al. Biochem J. 2009 May 13;420(2):221-7. doi: 10.1042/BJ20090110. Biochem J. 2009. PMID: 19275764 Free PMC article.

7

Substrate and product analogues as human O-GlcNAc transferase inhibitors.

Dorfmueller HC, Borodkin VS, Blair DE, Pathak S, Navratilova I, van Aalten DM. Dorfmueller HC, et al. Amino Acids. 2011 Mar;40(3):781-92. doi: 10.1007/s00726-010-0688-y. Epub 2010 Jul 17. Amino Acids. 2011. PMID: 20640461 Free PMC article.

8

Human OGA binds substrates in a conserved peptide recognition groove.

Schimpl M, Schüttelkopf AW, Borodkin VS, van Aalten DM. Schimpl M, et al. Biochem J. 2010 Nov 15;432(1):1-7. doi: 10.1042/BJ20101338. Biochem J. 2010. PMID: 20863279 Free PMC article.

9

An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold.

Borodkin VS, van Aalten DM. Borodkin VS, et al. Tetrahedron. 2010 Sep 25;66(39-3):7838-7849. doi: 10.1016/j.tet.2010.07.037. Tetrahedron. 2010. PMID: 20976183 Free PMC article.

10

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases.

Dorfmueller HC, Borodkin VS, Schimpl M, Zheng X, Kime R, Read KD, van Aalten DM. Dorfmueller HC, et al. Chem Biol. 2010 Nov 24;17(11):1250-5. doi: 10.1016/j.chembiol.2010.09.014. Chem Biol. 2010. PMID: 21095575 Free PMC article.

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