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Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Zamora Gonzalez N, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Angeli JPF, Bornstein SR, Tait SWG, Linkermann A. von Mässenhausen A, et al. Among authors: bornstein sr. Sci Adv. 2024 Mar 15;10(11):eadk7329. doi: 10.1126/sciadv.adk7329. Epub 2024 Mar 15. Sci Adv. 2024. PMID: 38489367 Free PMC article.
vPIF-1 is an insulin-like antiferroptotic viral peptide.
Belavgeni A, Maremonti F, Tonnus W, Stadtmüller M, Gavali S, Mallais M, Flade K, Brucker A, Becker JN, Beer K, Tmava M, Stumpf J, Gembardt F, Hugo C, Giacca M, Hale BG, Perakakis N, Sha W, Pratt DA, Schally AV, Bornstein SR, Linkermann A. Belavgeni A, et al. Among authors: bornstein sr. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2300320120. doi: 10.1073/pnas.2300320120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186845 Free PMC article.
Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis.
Perakakis N, Bornstein SR, Birkenfeld AL, Linkermann A, Demir M, Anker SD, Filippatos G, Pitt B, Rossing P, Ruilope LM, Kolkhof P, Lawatscheck R, Scott C, Bakris GL; FIDELIO-DKD and FIGARO-DKD investigators. Perakakis N, et al. Among authors: bornstein sr. Diabetes Obes Metab. 2024 Jan;26(1):191-200. doi: 10.1111/dom.15305. Epub 2023 Oct 10. Diabetes Obes Metab. 2024. PMID: 37814928
Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets.
Schepp F, Schubert U, Schmid J, Lehmann S, Latunde-Dada GO, Kose T, Steenblock C, Bornstein SR, Linkermann A, Ludwig B. Schepp F, et al. Among authors: bornstein sr. Horm Metab Res. 2024 Apr;56(4):279-285. doi: 10.1055/a-2190-2803. Epub 2023 Nov 13. Horm Metab Res. 2024. PMID: 37956864 Free article.
Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases.
Perakakis N, Harb H, Hale BG, Varga Z, Steenblock C, Kanczkowski W, Alexaki VI, Ludwig B, Mirtschink P, Solimena M, Toepfner N, Zeissig S, Gado M, Abela IA, Beuschlein F, Spinas GA, Cavelti-Weder C, Gerber PA, Huber M, Trkola A, Puhan MA, Wong WW, Linkermann A, Mohan V, Lehnert H, Nawroth P, Chavakis T, Mingrone G, Wolfrum C, Zinkernagel AS, Bornstein SR. Perakakis N, et al. Among authors: bornstein sr. Lancet Diabetes Endocrinol. 2023 Sep;11(9):675-693. doi: 10.1016/S2213-8587(23)00154-7. Epub 2023 Jul 28. Lancet Diabetes Endocrinol. 2023. PMID: 37524103 Review.
Asymmetric Adrenals: Sexual Dimorphism of Adrenal Tumors.
Bechmann N, Moskopp ML, Constantinescu G, Stell A, Ernst A, Berthold F, Westermann F, Jiang J, Lui L, Nowak E, Zopp S, Pacak K, Peitzsch M, Schedl A, Reincke M, Beuschlein F, Bornstein SR, Fassnacht M, Eisenhofer G. Bechmann N, et al. Among authors: bornstein sr. J Clin Endocrinol Metab. 2024 Jan 18;109(2):471-482. doi: 10.1210/clinem/dgad515. J Clin Endocrinol Metab. 2024. PMID: 37647861
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency.
Malyukov M, Gelfgat E, Ruiz-Babot G, Schmid J, Lehmann S, Spinas G, Beuschlein F, Hantel C, Reisch N, Nawroth PP, Bornstein SR, Steenblock C, Ludwig B. Malyukov M, et al. Among authors: bornstein sr. Xenotransplantation. 2023 Sep-Oct;30(5):e12819. doi: 10.1111/xen.12819. Epub 2023 Aug 7. Xenotransplantation. 2023. PMID: 37548062
Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice.
Gado M, Heinrich A, Wiedersich D, Sameith K, Dahl A, Alexaki VI, Swarbrick MM, Baschant U, Grafe I, Perakakis N, Bornstein SR, Rauner M, Hofbauer LC, Henneicke H. Gado M, et al. Among authors: bornstein sr. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E514-E530. doi: 10.1152/ajpendo.00259.2022. Epub 2023 Apr 26. Am J Physiol Endocrinol Metab. 2023. PMID: 37126848
799 results