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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Nat Commun. 2022 Jan 10;13(1):136. doi: 10.1038/s41467-021-27762-y.
Nat Commun. 2022.
PMID: 35013263
Free PMC article.
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR.
Simpson JB, et al. Among authors: borlandelli vb.
Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080/19490976.2022.2107289.
Gut Microbes. 2022.
PMID: 35953888
Free PMC article.
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β-l-Arabinofurano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases.
Borlandelli V, Offen W, Moroz O, Nin-Hill A, McGregor N, Binkhorst L, Ishiwata A, Armstrong Z, Artola M, Rovira C, Davies GJ, Overkleeft HS.
Borlandelli V, et al.
ACS Chem Biol. 2023 Dec 15;18(12):2564-2573. doi: 10.1021/acschembio.3c00558. Epub 2023 Dec 5.
ACS Chem Biol. 2023.
PMID: 38051515
Free PMC article.
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4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors.
Borlandelli V, Armstrong Z, Nin-Hill A, Codée JDC, Raich L, Artola M, Rovira C, Davies GJ, Overkleeft HS.
Borlandelli V, et al.
ChemMedChem. 2023 Feb 14;18(4):e202200580. doi: 10.1002/cmdc.202200580. Epub 2023 Jan 24.
ChemMedChem. 2023.
PMID: 36533564
Free PMC article.
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Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-l-Arabinofuranosidase Inhibitor.
McGregor NGS, Coines J, Borlandelli V, Amaki S, Artola M, Nin-Hill A, Linzel D, Yamada C, Arakawa T, Ishiwata A, Ito Y, van der Marel GA, Codée JDC, Fushinobu S, Overkleeft HS, Rovira C, Davies GJ.
McGregor NGS, et al. Among authors: borlandelli v.
Angew Chem Int Ed Engl. 2021 Mar 8;60(11):5754-5758. doi: 10.1002/anie.202013920. Epub 2021 Feb 2.
Angew Chem Int Ed Engl. 2021.
PMID: 33528085
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Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs.
Dal Corso A, Borlandelli V, Corno C, Perego P, Belvisi L, Pignataro L, Gennari C.
Dal Corso A, et al. Among authors: borlandelli v.
Angew Chem Int Ed Engl. 2020 Mar 2;59(10):4176-4181. doi: 10.1002/anie.201916394. Epub 2020 Jan 22.
Angew Chem Int Ed Engl. 2020.
PMID: 31881115
Free article.
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