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Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy.
Vidaurre S, Fitzpatrick C, Burzio VA, Briones M, Villota C, Villegas J, Echenique J, Oliveira-Cruz L, Araya M, Borgna V, Socías T, Lopez C, Avila R, Burzio LO. Vidaurre S, et al. Among authors: borgna v. J Biol Chem. 2014 Sep 26;289(39):27182-27198. doi: 10.1074/jbc.M114.558841. Epub 2014 Aug 6. J Biol Chem. 2014. PMID: 25100722 Free PMC article.
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors.
Lobos-González L, Silva V, Araya M, Restovic F, Echenique J, Oliveira-Cruz L, Fitzpatrick C, Briones M, Villegas J, Villota C, Vidaurre S, Borgna V, Socias M, Valenzuela S, Lopez C, Socias T, Varas M, Díaz J, Burzio LO, Burzio VA. Lobos-González L, et al. Among authors: borgna v. Oncotarget. 2016 Sep 6;7(36):58331-58350. doi: 10.18632/oncotarget.11110. Oncotarget. 2016. PMID: 27507060 Free PMC article.
Different cancers, same target?
Villegas J, Borgna V, Burzio VA. Villegas J, et al. Among authors: borgna v. Aging (Albany NY). 2017 Aug 8;9(8):1853-1854. doi: 10.18632/aging.101278. Aging (Albany NY). 2017. PMID: 28800297 Free PMC article. No abstract available.
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors.
Fitzpatrick C, Bendek MF, Briones M, Farfán N, Silva VA, Nardocci G, Montecino M, Boland A, Deleuze JF, Villegas J, Villota C, Silva V, Lobos-Gonzalez L, Borgna V, Barrey E, Burzio LO, Burzio VA. Fitzpatrick C, et al. Among authors: borgna v. Cell Death Dis. 2019 May 29;10(6):423. doi: 10.1038/s41419-019-1649-3. Cell Death Dis. 2019. PMID: 31142736 Free PMC article.
21 results