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RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF. Xu T, et al. Among authors: borggrefe t. EMBO J. 2017 Nov 2;36(21):3232-3249. doi: 10.15252/embj.201796525. Epub 2017 Oct 13. EMBO J. 2017. PMID: 29030483 Free PMC article.
Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.
Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T. Giaimo BD, et al. Among authors: borggrefe t. Nucleic Acids Res. 2018 Sep 19;46(16):8197-8215. doi: 10.1093/nar/gky551. Nucleic Acids Res. 2018. PMID: 29986055 Free PMC article.
The histone variant H2A.Z in gene regulation.
Giaimo BD, Ferrante F, Herchenröther A, Hake SB, Borggrefe T. Giaimo BD, et al. Among authors: borggrefe t. Epigenetics Chromatin. 2019 Jun 14;12(1):37. doi: 10.1186/s13072-019-0274-9. Epigenetics Chromatin. 2019. PMID: 31200754 Free PMC article. Review.
HDAC3 functions as a positive regulator in Notch signal transduction.
Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Klöble P, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: borggrefe t. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512. doi: 10.1093/nar/gkaa088. Nucleic Acids Res. 2020. PMID: 32107550 Free PMC article.
Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante F, Giaimo BD, Friedrich T, Sugino T, Mertens D, Kugler S, Gahr BM, Just S, Pan L, Bartkuhn M, Potente M, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: borggrefe t. Cell Death Dis. 2022 Jul 12;13(7):600. doi: 10.1038/s41419-022-05052-9. Cell Death Dis. 2022. PMID: 35821235 Free PMC article.
Notch-dependent and -independent functions of transcription factor RBPJ.
Friedrich T, Ferrante F, Pioger L, Nist A, Stiewe T, Andrau JC, Bartkuhn M, Giaimo BD, Borggrefe T. Friedrich T, et al. Among authors: borggrefe t. Nucleic Acids Res. 2022 Aug 12;50(14):7925-7937. doi: 10.1093/nar/gkac601. Nucleic Acids Res. 2022. PMID: 35848919 Free PMC article.
Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase.
Merle N, Elmshäuser S, Strassheimer F, Wanzel M, König AM, Funk J, Neumann M, Kochhan K, Helmprobst F, Pagenstecher A, Nist A, Mernberger M, Schneider A, Braun T, Borggrefe T, Savai R, Timofeev O, Stiewe T. Merle N, et al. Among authors: borggrefe t. Mol Cancer. 2022 Oct 3;21(1):191. doi: 10.1186/s12943-022-01661-2. Mol Cancer. 2022. PMID: 36192757 Free PMC article.
66 results