Bordet T - Search Results

1

Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound.

Bordet T, Berna P, Abitbol JL, Pruss RM. Bordet T, et al. Pharmaceuticals (Basel). 2010 Jan 28;3(2):345-368. doi: 10.3390/ph3020345. Pharmaceuticals (Basel). 2010. PMID: 27713255 Free PMC article. Review.

2

Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.

Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, Delaage M, Henderson CE, Pruss RM. Bordet T, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20. doi: 10.1124/jpet.107.123000. Epub 2007 May 11. J Pharmacol Exp Ther. 2007. PMID: 17496168

3

Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy.

Bordet T, Buisson B, Michaud M, Abitbol JL, Marchand F, Grist J, Andriambeloson E, Malcangio M, Pruss RM. Bordet T, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):623-32. doi: 10.1124/jpet.108.139410. Epub 2008 May 20. J Pharmacol Exp Ther. 2008. PMID: 18492948

4

TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition.

Schaller S, Paradis S, Ngoh GA, Assaly R, Buisson B, Drouot C, Ostuni MA, Lacapere JJ, Bassissi F, Bordet T, Berdeaux A, Jones SP, Morin D, Pruss RM. Schaller S, et al. Among authors: bordet t. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706. doi: 10.1124/jpet.110.167486. Epub 2010 Mar 9. J Pharmacol Exp Ther. 2010. PMID: 20215409 Free article.

5

Drug discovery and development for spinal muscular atrophy: lessons from screening approaches and future challenges for clinical development.

Pruss RM, Giraudon-Paoli M, Morozova S, Berna P, Abitbol JL, Bordet T. Pruss RM, et al. Among authors: bordet t. Future Med Chem. 2010 Sep;2(9):1429-40. doi: 10.4155/fmc.10.228. Future Med Chem. 2010. PMID: 21426138 Free article.

6

Olesoxime accelerates myelination and promotes repair in models of demyelination.

Magalon K, Zimmer C, Cayre M, Khaldi J, Bourbon C, Robles I, Tardif G, Viola A, Pruss RM, Bordet T, Durbec P. Magalon K, et al. Among authors: bordet t. Ann Neurol. 2012 Feb;71(2):213-26. doi: 10.1002/ana.22593. Ann Neurol. 2012. PMID: 22367994

7

Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF.

Gouarné C, Giraudon-Paoli M, Seimandi M, Biscarrat C, Tardif G, Pruss RM, Bordet T. Gouarné C, et al. Among authors: bordet t. Br J Pharmacol. 2013 Apr;168(8):1975-88. doi: 10.1111/bph.12094. Br J Pharmacol. 2013. PMID: 23278424 Free PMC article.

8

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP. Clemens LE, et al. Among authors: bordet t. Brain. 2015 Dec;138(Pt 12):3632-53. doi: 10.1093/brain/awv290. Epub 2015 Oct 21. Brain. 2015. PMID: 26490331

9

Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model.

Sunyach C, Michaud M, Arnoux T, Bernard-Marissal N, Aebischer J, Latyszenok V, Gouarné C, Raoul C, Pruss RM, Bordet T, Pettmann B. Sunyach C, et al. Among authors: bordet t. Neuropharmacology. 2012 Jun;62(7):2346-52. doi: 10.1016/j.neuropharm.2012.02.013. Epub 2012 Feb 20. Neuropharmacology. 2012. PMID: 22369784

10

Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.

Gouarné C, Tracz J, Paoli MG, Deluca V, Seimandi M, Tardif G, Xilouri M, Stefanis L, Bordet T, Pruss RM. Gouarné C, et al. Among authors: bordet t. Br J Pharmacol. 2015 Jan;172(1):235-45. doi: 10.1111/bph.12939. Epub 2014 Dec 1. Br J Pharmacol. 2015. PMID: 25220617 Free PMC article.

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