Borcherds WM - Search Results

1

Conformational buffering underlies functional selection in intrinsically disordered protein regions.

González-Foutel NS, Glavina J, Borcherds WM, Safranchik M, Barrera-Vilarmau S, Sagar A, Estaña A, Barozet A, Garrone NA, Fernandez-Ballester G, Blanes-Mira C, Sánchez IE, de Prat-Gay G, Cortés J, Bernadó P, Pappu RV, Holehouse AS, Daughdrill GW, Chemes LB. González-Foutel NS, et al. Among authors: borcherds wm. Nat Struct Mol Biol. 2022 Aug;29(8):781-790. doi: 10.1038/s41594-022-00811-w. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948766 Free PMC article.

2

Disorder predictors also predict backbone dynamics for a family of disordered proteins.

Daughdrill GW, Borcherds WM, Wu H. Daughdrill GW, et al. Among authors: borcherds wm. PLoS One. 2011;6(12):e29207. doi: 10.1371/journal.pone.0029207. Epub 2011 Dec 15. PLoS One. 2011. PMID: 22195023 Free PMC article.

3

Using chemical shifts to assess transient secondary structure and generate ensemble structures of intrinsically disordered proteins.

Kashtanov S, Borcherds W, Wu H, Daughdrill GW, Ytreberg FM. Kashtanov S, et al. Methods Mol Biol. 2012;895:139-52. doi: 10.1007/978-1-61779-927-3_11. Methods Mol Biol. 2012. PMID: 22760318

4

Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins.

Borcherds W, Kashtanov S, Wu H, Daughdrill GW. Borcherds W, et al. Proteins. 2013 Oct;81(10):1686-98. doi: 10.1002/prot.24303. Epub 2013 Jul 23. Proteins. 2013. PMID: 23606624

5

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.

Borcherds W, Theillet FX, Katzer A, Finzel A, Mishall KM, Powell AT, Wu H, Manieri W, Dieterich C, Selenko P, Loewer A, Daughdrill GW. Borcherds W, et al. Nat Chem Biol. 2014 Dec;10(12):1000-2. doi: 10.1038/nchembio.1668. Epub 2014 Nov 2. Nat Chem Biol. 2014. PMID: 25362358

6

Autoinhibition of MDMX by intramolecular p53 mimicry.

Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Chen L, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4624-9. doi: 10.1073/pnas.1420833112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825738 Free PMC article.

7

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

Wei X, Wu S, Song T, Chen L, Gao M, Borcherds W, Daughdrill GW, Chen J. Wei X, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2558-63. doi: 10.1073/pnas.1603838113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114532 Free PMC article.

8

Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure.

Ytreberg FM, Borcherds W, Wu H, Daughdrill GW. Ytreberg FM, et al. Intrinsically Disord Proteins. 2015 Feb 3;3(1):e984565. doi: 10.4161/21690707.2014.984565. eCollection 2015. Intrinsically Disord Proteins. 2015. PMID: 28232883 Free PMC article.

9

Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.

Crabtree MD, Borcherds W, Poosapati A, Shammas SL, Daughdrill GW, Clarke J. Crabtree MD, et al. Biochemistry. 2017 May 9;56(18):2379-2384. doi: 10.1021/acs.biochem.7b00179. Epub 2017 Apr 26. Biochemistry. 2017. PMID: 28425697 Free PMC article.

10

Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX.

Borcherds W, Becker A, Chen L, Chen J, Chemes LB, Daughdrill GW. Borcherds W, et al. Biophys J. 2017 May 23;112(10):2038-2042. doi: 10.1016/j.bpj.2017.04.017. Epub 2017 May 6. Biophys J. 2017. PMID: 28487147 Free PMC article.

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