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"Selective" serotonin 5-HT2A receptor antagonists.
Casey AB, Cui M, Booth RG, Canal CE. Casey AB, et al. Among authors: booth rg. Biochem Pharmacol. 2022 Jun;200:115028. doi: 10.1016/j.bcp.2022.115028. Epub 2022 Apr 4. Biochem Pharmacol. 2022. PMID: 35381208 Free PMC article. Review.
(S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
Armstrong JL, Casey AB, Saraf TS, Mukherjee M, Booth RG, Canal CE. Armstrong JL, et al. Among authors: booth rg. ACS Pharmacol Transl Sci. 2020 Feb 21;3(3):509-523. doi: 10.1021/acsptsci.9b00101. eCollection 2020 Jun 12. ACS Pharmacol Transl Sci. 2020. PMID: 32566916 Free PMC article.
Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands.
Canal CE, Cordova-Sintjago T, Liu Y, Kim MS, Morgan D, Booth RG. Canal CE, et al. Among authors: booth rg. J Pharmacol Exp Ther. 2013 Dec;347(3):705-16. doi: 10.1124/jpet.113.208637. Epub 2013 Sep 30. J Pharmacol Exp Ther. 2013. PMID: 24080681 Free PMC article.
A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.
Canal CE, Morgan D, Felsing D, Kondabolu K, Rowland NE, Robertson KL, Sakhuja R, Booth RG. Canal CE, et al. Among authors: booth rg. J Pharmacol Exp Ther. 2014 May;349(2):310-8. doi: 10.1124/jpet.113.212373. Epub 2014 Feb 21. J Pharmacol Exp Ther. 2014. PMID: 24563531 Free PMC article.
Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.
Sakhuja R, Kondabolu K, Córdova-Sintjago T, Travers S, Vincek AS, Kim MS, Abboud KA, Fang L, Sun Z, Canal CE, Booth RG. Sakhuja R, et al. Among authors: booth rg. Bioorg Med Chem. 2015 Apr 1;23(7):1588-600. doi: 10.1016/j.bmc.2015.01.060. Epub 2015 Feb 7. Bioorg Med Chem. 2015. PMID: 25703249 Free PMC article.
135 results