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TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells.
Cianciotti BC, Magnani ZI, Ugolini A, Camisa B, Merelli I, Vavassori V, Potenza A, Imparato A, Manfredi F, Abbati D, Perani L, Spinelli A, Shifrut E, Ciceri F, Vago L, Di Micco R, Naldini L, Genovese P, Ruggiero E, Bonini C. Cianciotti BC, et al. Among authors: bonini c. Front Immunol. 2024 Feb 29;15:1315283. doi: 10.3389/fimmu.2024.1315283. eCollection 2024. Front Immunol. 2024. PMID: 38510235 Free PMC article.
Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy.
Galli F, Bragg L, Rossi M, Proietti D, Perani L, Bagicaluppi M, Tonlorenzi R, Sibanda T, Caffarini M, Talapatra A, Santoleri S, Meregalli M, Bano-Otalora B, Bigot A, Bozzoni I, Bonini C, Mouly V, Torrente Y, Cossu G. Galli F, et al. Among authors: bonini c. EMBO Mol Med. 2024 Apr;16(4):927-944. doi: 10.1038/s44321-024-00031-3. Epub 2024 Mar 4. EMBO Mol Med. 2024. PMID: 38438561 Free PMC article.
The rs11568820 Variant in the Promoter Region of Vitamin D Receptor Gene Is Associated with Clinical Remission in Rheumatoid Arthritis Patients Receiving Tumor Necrosis Factor Inhibitors.
Latini A, De Benedittis G, Conigliaro P, Bonini C, Morgante C, Iacovantuono M, D'Antonio A, Bergamini A, Novelli G, Chimenti MS, Ciccacci C, Borgiani P. Latini A, et al. Among authors: bonini c. Genes (Basel). 2024 Feb 12;15(2):234. doi: 10.3390/genes15020234. Genes (Basel). 2024. PMID: 38397223 Free PMC article.
Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity.
Giovenzana A, Bezzecchi E, Bichisecchi A, Cardellini S, Ragogna F, Pedica F, Invernizzi F, Di Filippo L, Tomajer V, Aleotti F, Scotti GM, Socci C, Cesana G, Olmi S, Morelli MJ, Falconi M, Giustina A, Bonini C, Piemonti L, Ruggiero E, Petrelli A. Giovenzana A, et al. Among authors: bonini c. iScience. 2024 Feb 1;27(3):109032. doi: 10.1016/j.isci.2024.109032. eCollection 2024 Mar 15. iScience. 2024. PMID: 38380252 Free PMC article.
Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.
Manfredi F, Stasi L, Buonanno S, Marzuttini F, Noviello M, Mastaglio S, Abbati D, Potenza A, Balestrieri C, Cianciotti BC, Tassi E, Feola S, Toffalori C, Punta M, Magnani Z, Camisa B, Tiziano E, Lupo-Stanghellini MT, Branca RM, Lehtiö J, Sikanen TM, Haapala MJ, Cerullo V, Casucci M, Vago L, Ciceri F, Bonini C, Ruggiero E. Manfredi F, et al. Among authors: bonini c. Sci Adv. 2023 Dec;9(48):eadg8014. doi: 10.1126/sciadv.adg8014. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039364 Free PMC article.
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer.
Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro A, Ng MSF, Schiavo Lena M, Drago D, Andolfo A, Brugiapaglia S, Scagliotti A, Mortellaro A, Corbo V, Liu Z, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R. Caronni N, et al. Among authors: bonini c. Nature. 2023 Nov;623(7986):415-422. doi: 10.1038/s41586-023-06685-2. Epub 2023 Nov 1. Nature. 2023. PMID: 37914939 Free article.
Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells.
Tassi E, Bergamini A, Wignall J, Sant'Angelo M, Brunetto E, Balestrieri C, Redegalli M, Potenza A, Abbati D, Manfredi F, Cangi MG, Magliacane G, Scalisi F, Ruggiero E, Maffia MC, Trippitelli F, Rabaiotti E, Cioffi R, Bocciolone L, Candotti G, Candiani M, Taccagni G, Schultes B, Doglioni C, Mangili G, Bonini C. Tassi E, et al. Among authors: bonini c. Front Immunol. 2023 Oct 4;14:1212444. doi: 10.3389/fimmu.2023.1212444. eCollection 2023. Front Immunol. 2023. PMID: 37868997 Free PMC article.
233 results