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Pharmacological targeting of G protein-coupled receptor heteromers.
Moreno E, Casajuana-Martin N, Coyle M, Campos BC, Galaj E, Del Torrent CL, Seyedian A, Rea W, Cai NS, Bonifazi A, Florán B, Xi ZX, Guitart X, Casadó V, Newman AH, Bishop C, Pardo L, Ferré S. Moreno E, et al. Among authors: bonifazi a. Pharmacol Res. 2022 Nov;185:106476. doi: 10.1016/j.phrs.2022.106476. Epub 2022 Sep 28. Pharmacol Res. 2022. PMID: 36182040 Free PMC article.
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH. Keck TM, et al. Among authors: bonifazi a. Bioorg Med Chem. 2015 Jul 15;23(14):4000-12. doi: 10.1016/j.bmc.2015.01.017. Epub 2015 Jan 17. Bioorg Med Chem. 2015. PMID: 25650314 Free PMC article.
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus.
Mammoli V, Bonifazi A, Dal Ben D, Giannella M, Giorgioni G, Piergentili A, Pigini M, Quaglia W, Thomas A, Newman AH, Ferré S, Sanchez-Soto M, Keck TM, Del Bello F. Mammoli V, et al. Among authors: bonifazi a. ChemMedChem. 2016 Aug 19;11(16):1819-28. doi: 10.1002/cmdc.201600022. Epub 2016 Mar 15. ChemMedChem. 2016. PMID: 26990230 Free PMC article.
Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.
Zou MF, Keck TM, Kumar V, Donthamsetti P, Michino M, Burzynski C, Schweppe C, Bonifazi A, Free RB, Sibley DR, Janowsky A, Shi L, Javitch JA, Newman AH. Zou MF, et al. Among authors: bonifazi a. J Med Chem. 2016 Apr 14;59(7):2973-88. doi: 10.1021/acs.jmedchem.5b01612. Epub 2016 Apr 1. J Med Chem. 2016. PMID: 27035329 Free PMC article.
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.
Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Kumar V, et al. Among authors: bonifazi a. J Med Chem. 2016 Aug 25;59(16):7634-50. doi: 10.1021/acs.jmedchem.6b00860. Epub 2016 Aug 10. J Med Chem. 2016. PMID: 27508895 Free PMC article.
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH. Cao J, et al. Among authors: bonifazi a. J Med Chem. 2016 Dec 8;59(23):10676-10691. doi: 10.1021/acs.jmedchem.6b01373. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933960 Free PMC article.
Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.
Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Michino M, et al. Among authors: bonifazi a. J Med Chem. 2017 Jan 26;60(2):580-593. doi: 10.1021/acs.jmedchem.6b01148. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27983845 Free PMC article.
Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).
Kumar V, Moritz AE, Keck TM, Bonifazi A, Ellenberger MP, Sibley CD, Free RB, Shi L, Lane JR, Sibley DR, Newman AH. Kumar V, et al. Among authors: bonifazi a. J Med Chem. 2017 Feb 23;60(4):1478-1494. doi: 10.1021/acs.jmedchem.6b01688. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28186762 Free PMC article.
74 results