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Page 1
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Ivanochko D, Fabra-García A, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Newton J, Semesi A, de Bruijni M, Bolscher J, Ramjith J, Szabat M, Vogt S, Kraft L, Duncan S, Lee SM, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Sauerwein RW, Richter King C, MacGill RS, Bousema T, Jore MM, Julien JP. Ivanochko D, et al. Among authors: bolscher j. Immunity. 2023 Feb 14;56(2):420-432.e7. doi: 10.1016/j.immuni.2023.01.013. Immunity. 2023. PMID: 36792575 Free PMC article.
Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate--Tackling the Cocktail Challenge.
Boes A, Spiegel H, Voepel N, Edgue G, Beiss V, Kapelski S, Fendel R, Scheuermayer M, Pradel G, Bolscher JM, Behet MC, Dechering KJ, Hermsen CC, Sauerwein RW, Schillberg S, Reimann A, Fischer R. Boes A, et al. Among authors: bolscher jm. PLoS One. 2015 Jul 6;10(7):e0131456. doi: 10.1371/journal.pone.0131456. eCollection 2015. PLoS One. 2015. PMID: 26147206 Free PMC article.
Functional antibodies against Plasmodium falciparum sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso.
Barry A, Behet MC, Nébié I, Lanke K, Grignard L, Ouedraogo A, Soulama I, Drakeley C, Sauerwein R, Bolscher JM, Dechering KJ, Bousema T, Tiono AB, Gonçalves BP. Barry A, et al. Among authors: bolscher jm. Wellcome Open Res. 2019 May 1;3:159. doi: 10.12688/wellcomeopenres.14932.2. eCollection 2018. Wellcome Open Res. 2019. PMID: 30828645 Free PMC article.
A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages.
Marin-Mogollon C, Salman AM, Koolen KMJ, Bolscher JM, van Pul FJA, Miyazaki S, Imai T, Othman AS, Ramesar J, van Gemert GJ, Kroeze H, Chevalley-Maurel S, Franke-Fayard B, Sauerwein RW, Hill AVS, Dechering KJ, Janse CJ, Khan SM. Marin-Mogollon C, et al. Among authors: bolscher jm. Front Cell Infect Microbiol. 2019 Apr 16;9:96. doi: 10.3389/fcimb.2019.00096. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31058097 Free PMC article.
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM, Vos MW, Miller K, Reeves SA, Pett H, Trevitt G, Wittlin S, Scheurer C, Sax S, Fischli C, Angulo-Barturen I, Jiménez-Diaz MB, Josling G, Kooij TWA, Bonnert R, Campo B, Blaauw RH, Rutjes FPJT, Sauerwein RW, Llinás M, Hermkens PHH, Dechering KJ. Schalkwijk J, et al. Among authors: bolscher jm. Sci Transl Med. 2019 Sep 18;11(510):eaas9917. doi: 10.1126/scitranslmed.aas9917. Sci Transl Med. 2019. PMID: 31534021
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA, Rosenthal PJ, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. de Vries LE, et al. Among authors: bolscher jm. Nat Commun. 2022 Apr 20;13(1):2158. doi: 10.1038/s41467-022-29688-5. Nat Commun. 2022. PMID: 35444200 Free PMC article.
Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.
Fabra-García A, Hailemariam S, de Jong RM, Janssen K, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Ivanochko D, Semesi A, McLeod B, Vos MW, de Bruijni MHC, Bolscher JM, Szabat M, Vogt S, Kraft L, Duncan S, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Dechering KJ, Sauerwein RW, King CR, MacGill RS, Bousema T, Julien JP, Jore MM. Fabra-García A, et al. Among authors: bolscher jm. Immunity. 2023 Feb 14;56(2):406-419.e7. doi: 10.1016/j.immuni.2023.01.009. Immunity. 2023. PMID: 36792574 Free PMC article.
Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.
B Henry N, Soulama I, S Sermé S, Bolscher JM, T G Huijs T, S Coulibaly A, Sombié S, Ouédraogo N, Diarra A, Zongo S, Guelbéogo WM, Nébié I, Sirima SB, Tiono AB, Pietro A, Collins KA, Dechering KJ, Bousema T. B Henry N, et al. Among authors: bolscher jm. PLoS One. 2023 Jul 26;18(7):e0284751. doi: 10.1371/journal.pone.0284751. eCollection 2023. PLoS One. 2023. PMID: 37494413 Free PMC article.
140 results