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Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.
Reichstetter S, Castillo GM, Rubinstein I, Nishimoto-Ashfield A, Lai M, Jones CC, Banerjee AA, Lyubimov A, Bloedow DC, Bogdanov A Jr, Bolotin EM. Reichstetter S, et al. Among authors: bolotin em. Pharm Res. 2013 Mar;30(3):670-82. doi: 10.1007/s11095-012-0904-4. Epub 2012 Dec 7. Pharm Res. 2013. PMID: 23224976 Free PMC article.
Protected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus® (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study.
Reichstetter S, Castillo GM, Lai M, Nishimoto-Ashfield A, Banerjee A, Bogdanov A, Lyubimov AV, Bolotin EM. Reichstetter S, et al. Among authors: bolotin em. Pharm Res. 2012 Apr;29(4):1033-9. doi: 10.1007/s11095-011-0646-8. Epub 2011 Dec 28. Pharm Res. 2012. PMID: 22203325