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Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.
Stanton C, Sun J, Nutsch K, Rosarda JD, Nguyen T, Li-Ma C, Kutseikin S, Saez E, Teijaro JR, Wiseman RL, Bollong MJ. Stanton C, et al. Among authors: bollong mj. bioRxiv [Preprint]. 2023 Jun 1:2023.06.01.543248. doi: 10.1101/2023.06.01.543248. bioRxiv. 2023. PMID: 37398499 Free PMC article. Updated. Preprint.
Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.
Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG. Staerk J, et al. Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5. Angew Chem Int Ed Engl. 2011. PMID: 21547985 Free PMC article. No abstract available.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, Chatterjee AK, Shen W, Camargo FD, Schultz PG, Bollong MJ. Shalhout SZ, et al. Among authors: bollong mj. Nat Chem Biol. 2021 Jul;17(7):767-775. doi: 10.1038/s41589-021-00755-0. Epub 2021 Mar 15. Nat Chem Biol. 2021. PMID: 33723431
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Jo J, Kim J, Ibrahim L, Kumar M, Iaconelli J, Tran CS, Moon HR, Jung Y, Wiseman RL, Lairson LL, Chatterjee AK, Bollong MJ, Yun H. Jo J, et al. Among authors: bollong mj. Bioorg Med Chem Lett. 2023 Jun 1;89:129306. doi: 10.1016/j.bmcl.2023.129306. Epub 2023 Apr 26. Bioorg Med Chem Lett. 2023. PMID: 37116763
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko Y, Hong M, Lee S, Kumar M, Ibrahim L, Nutsch K, Stanton C, Sondermann P, Sandoval B, Bulos ML, Iaconelli J, Chatterjee AK, Wiseman RL, Schultz PG, Bollong MJ. Ko Y, et al. Among authors: bollong mj. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120. doi: 10.1073/pnas.2300763120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155889 Free PMC article.
33 results