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Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ. Hua T, et al. Among authors: bohn lm. Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30. Cell. 2020. PMID: 32004463 Free PMC article.
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Zhou L, et al. Among authors: bohn lm. J Biol Chem. 2013 Dec 20;288(51):36703-16. doi: 10.1074/jbc.M113.504381. Epub 2013 Nov 1. J Biol Chem. 2013. PMID: 24187130 Free PMC article.
Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.
Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Lovell KM, et al. Among authors: bohn lm. ACS Chem Neurosci. 2015 Aug 19;6(8):1411-9. doi: 10.1021/acschemneuro.5b00092. Epub 2015 May 1. ACS Chem Neurosci. 2015. PMID: 25891774 Free PMC article.
Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.
Janero DR, Yaddanapudi S, Zvonok N, Subramanian KV, Shukla VG, Stahl E, Zhou L, Hurst D, Wager-Miller J, Bohn LM, Reggio PH, Mackie K, Makriyannis A. Janero DR, et al. Among authors: bohn lm. ACS Chem Neurosci. 2015 Aug 19;6(8):1400-10. doi: 10.1021/acschemneuro.5b00090. Epub 2015 May 29. ACS Chem Neurosci. 2015. PMID: 25978068 Free PMC article.
Crystal Structure of the Human Cannabinoid Receptor CB1.
Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Among authors: bohn lm. Cell. 2016 Oct 20;167(3):750-762.e14. doi: 10.1016/j.cell.2016.10.004. Cell. 2016. PMID: 27768894 Free PMC article.
Crystal structures of agonist-bound human cannabinoid receptor CB1.
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Among authors: bohn lm. Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5. Nature. 2017. PMID: 28678776 Free PMC article.
Approaches to Assess Biased Signaling at the CB1R Receptor.
Laprairie RB, Stahl EL, Bohn LM. Laprairie RB, et al. Among authors: bohn lm. Methods Enzymol. 2017;593:259-279. doi: 10.1016/bs.mie.2017.06.031. Epub 2017 Jul 5. Methods Enzymol. 2017. PMID: 28750807 Free PMC article.
113 results