G13A substitution affects the biochemical and physical properties of the elongation factor 1 alpha. A reduced intrinsic GTPase activity is partially restored by kirromycin.
Masullo M, Cantiello P, de Paola B, Catanzano F, Arcari P, Bocchini V.
Masullo M, et al. Among authors: bocchini v.
Biochemistry. 2002 Jan 15;41(2):628-33. doi: 10.1021/bi015598h.
Biochemistry. 2002.
PMID: 11781103
., Adinolfi, B. S., Amatruda, M. R., Raimo, G., Masullo, M., and Bocchini, V. (1994) Eur. J. Biochem. 262, 600-605]. In this work, we found that, compared to the wild-type factor (SsEF-1 alpha wt), G13ASsEF-1 alpha shows (i) a reduced rate of [(3)H]Phe polymerizatio …
., Adinolfi, B. S., Amatruda, M. R., Raimo, G., Masullo, M., and Bocchini, V. (1994) Eur. J. Biochem. 262, 600-605]. In this w …