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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. McQuade A, et al. Nat Commun. 2020 Oct 23;11(1):5370. doi: 10.1038/s41467-020-19227-5. Nat Commun. 2020. PMID: 33097708 Free PMC article.
Inflammatory changes parallel the early stages of Alzheimer disease.
Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Parachikova A, et al. Neurobiol Aging. 2007 Dec;28(12):1821-33. doi: 10.1016/j.neurobiolaging.2006.08.014. Epub 2006 Oct 18. Neurobiol Aging. 2007. PMID: 17052803 Free PMC article.
β-Amyloid impairs axonal BDNF retrograde trafficking.
Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. Poon WW, et al. Neurobiol Aging. 2011 May;32(5):821-33. doi: 10.1016/j.neurobiolaging.2009.05.012. Epub 2009 Jun 21. Neurobiol Aging. 2011. PMID: 19540623 Free PMC article.
Soluble aβ promotes wild-type tau pathology in vivo.
Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. Chabrier MA, et al. J Neurosci. 2012 Nov 28;32(48):17345-50. doi: 10.1523/JNEUROSCI.0172-12.2012. J Neurosci. 2012. PMID: 23197725 Free PMC article.
94 results