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IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum.
Brabec T, Vobořil M, Schierová D, Valter E, Šplíchalová I, Dobeš J, Březina J, Dobešová M, Aidarova A, Jakubec M, Manning J, Blumberg R, Waisman A, Kolář M, Kubovčiak J, Šrůtková D, Hudcovic T, Schwarzer M, Froňková E, Pinkasová T, Jabandžiev P, Filipp D. Brabec T, et al. Among authors: blumberg r. Mucosal Immunol. 2023 Aug;16(4):373-385. doi: 10.1016/j.mucimm.2023.01.005. Epub 2023 Feb 3. Mucosal Immunol. 2023. PMID: 36739089 Free article.
Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress.
Martín-Adrados B, Wculek SK, Fernández-Bravo S, Torres-Ruiz R, Valle-Noguera A, Gomez-Sánchez MJ, Hernández-Walias JC, Ferreira FM, Corraliza AM, Sancho D, Esteban V, Rodriguez-Perales S, Cruz-Adalia A, Nakaya HI, Salas A, Bernardo D, Campos-Martín Y, Martínez-Zamorano E, Muñoz-López D, Gómez Del Moral M, Cubero FJ, Blumberg RS, Martínez-Naves E. Martín-Adrados B, et al. Among authors: blumberg rs. Front Immunol. 2023 Jun 30;14:1185517. doi: 10.3389/fimmu.2023.1185517. eCollection 2023. Front Immunol. 2023. PMID: 37457727 Free PMC article.
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.
Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS. Duan J, et al. Among authors: blumberg rs. Immunity. 2023 May 9;56(5):1115-1131.e9. doi: 10.1016/j.immuni.2023.02.018. Epub 2023 Mar 13. Immunity. 2023. PMID: 36917985 Free PMC article.
T Cell CEACAM1-TIM-3 Crosstalk Alleviates Liver Transplant Injury in Mice and Humans.
Kojima H, Kadono K, Hirao H, Dery KJ, Torgerson T, Yao S, Kaldas FM, Farmer DG, Blumberg RS, Kupiec-Weglinski JW. Kojima H, et al. Among authors: blumberg rs. Gastroenterology. 2023 Nov;165(5):1233-1248.e9. doi: 10.1053/j.gastro.2023.07.004. Epub 2023 Jul 19. Gastroenterology. 2023. PMID: 37479191 Free article.
Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut.
Becker B, Wottawa F, Bakr M, Koncina E, Mayr L, Kugler J, Yang G, Windross SJ, Neises L, Mishra N, Harris D, Tran F, Welz L, Schwärzler J, Bánki Z, Stengel ST, Ito G, Krötz C, Coleman OI, Jaeger C, Haller D, Paludan SR, Blumberg R, Kaser A, Cicin-Sain L, Schreiber S, Adolph TE, Letellier E, Rosenstiel P, Meiser J, Aden K. Becker B, et al. Among authors: blumberg r. iScience. 2024 Feb 8;27(3):109173. doi: 10.1016/j.isci.2024.109173. eCollection 2024 Mar 15. iScience. 2024. PMID: 38496294 Free PMC article.
IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation.
Singh A, Beaupre M, Villegas-Novoa C, Shiomitsu K, Gaudino SJ, Tawch S, Damle R, Kempen C, Choudhury B, McAleer JP, Sheridan BS, Denoya P, Blumberg RS, Hearing P, Allbritton NL, Kumar P. Singh A, et al. Among authors: blumberg rs. Cell Rep. 2024 May 10;43(5):114206. doi: 10.1016/j.celrep.2024.114206. Online ahead of print. Cell Rep. 2024. PMID: 38733584 Free article.
Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders.
Gaudino SJ, Singh A, Huang H, Padiadpu J, Jean-Pierre M, Kempen C, Bahadur T, Shiomitsu K, Blumberg R, Shroyer KR, Beyaz S, Shulzhenko N, Morgun A, Kumar P. Gaudino SJ, et al. Among authors: blumberg r. Nat Commun. 2024 Feb 21;15(1):1597. doi: 10.1038/s41467-024-45568-6. Nat Commun. 2024. PMID: 38383607 Free PMC article.
416 results