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Page 1
Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines.
Moas-Héloire V, Renault N, Batalha V, Arias AR, Marchivie M, Yous S, Deguine N, Buée L, Chavatte P, Blum D, Lopes L, Melnyk P, Agouridas L. Moas-Héloire V, et al. Among authors: blum d. Eur J Med Chem. 2015 Dec 1;106:15-25. doi: 10.1016/j.ejmech.2015.10.030. Epub 2015 Oct 19. Eur J Med Chem. 2015. PMID: 26513641 Free article.
A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.
Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Mariciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D. Laurent C, et al. Among authors: d hooge r, blum d. Mol Psychiatry. 2016 Jan;21(1):97-107. doi: 10.1038/mp.2014.151. Epub 2014 Dec 2. Mol Psychiatry. 2016. PMID: 25450226
Stabilizing synapses.
Blum D, Lopes LV. Blum D, et al. Science. 2021 Nov 5;374(6568):684-685. doi: 10.1126/science.abm3902. Epub 2021 Nov 4. Science. 2021. PMID: 34735229
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV. Batalha VL, et al. Among authors: blum d. Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493. Sci Rep. 2016. PMID: 27510168 Free PMC article.
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.
Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV. Temido-Ferreira M, et al. Among authors: blum d. Mol Psychiatry. 2020 Aug;25(8):1876-1900. doi: 10.1038/s41380-018-0110-9. Epub 2018 Jun 27. Mol Psychiatry. 2020. PMID: 29950682 Free PMC article.
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.
Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D. Faivre E, et al. Among authors: blum d. Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30050407 Free PMC article.
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.
Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Gras SL, Dumoulin M, Cellai L; NeuroCEB Brain Bank; Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D. Carvalho K, et al. Among authors: blum d. Brain. 2019 Nov 1;142(11):3636-3654. doi: 10.1093/brain/awz288. Brain. 2019. PMID: 31599329 Free PMC article.
From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?
Flaten V, Laurent C, Coelho JE, Sandau U, Batalha VL, Burnouf S, Hamdane M, Humez S, Boison D, Lopes LV, Buée L, Blum D. Flaten V, et al. Among authors: blum d. Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229. Biochem Soc Trans. 2014. PMID: 24646282 Free PMC article. Review.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P. Sergeant N, et al. Among authors: blum d. Neurobiol Dis. 2019 Sep;129:217-233. doi: 10.1016/j.nbd.2019.03.028. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928644
589 results