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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
Wright SC, Motso A, Koutsilieri S, Beusch CM, Sabatier P, Berghella A, Blondel-Tepaz É, Mangenot K, Pittarokoilis I, Sismanoglou DC, Le Gouill C, Olsen JV, Zubarev RA, Lambert NA, Hauser AS, Bouvier M, Lauschke VM. Wright SC, et al. Among authors: blondel tepaz e. Nat Commun. 2023 Oct 9;14(1):6243. doi: 10.1038/s41467-023-41893-4. Nat Commun. 2023. PMID: 37813859 Free PMC article.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.
Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, Blondel-Tepaz É, Antunes Vieira N, Costa-Neto C, Héroux M, Lambert NA, Parreiras-E-Silva LT, Bouvier M. Wright SC, et al. Among authors: blondel tepaz e. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2025846118. doi: 10.1073/pnas.2025846118. Proc Natl Acad Sci U S A. 2021. PMID: 33990469 Free PMC article.
Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.
Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M. Paradis JS, et al. Among authors: blondel tepaz e. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5160-8. doi: 10.1073/pnas.1508836112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324936 Free PMC article.
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.
Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGH. Blondel-Tepaz E, et al. Oncogene. 2021 Mar;40(12):2243-2257. doi: 10.1038/s41388-021-01704-w. Epub 2021 Mar 1. Oncogene. 2021. PMID: 33649538 Free article.
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor.
Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Pastor AM, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M. Gaitonde SA, et al. Among authors: blondel tepaz e. Mol Psychiatry. 2024 Apr 2. doi: 10.1038/s41380-024-02531-7. Online ahead of print. Mol Psychiatry. 2024. PMID: 38561467