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Drug discovery targeting amino acid racemases.
Conti P, Tamborini L, Pinto A, Blondel A, Minoprio P, Mozzarelli A, De Micheli C. Conti P, et al. Among authors: blondel a. Chem Rev. 2011 Nov 9;111(11):6919-46. doi: 10.1021/cr2000702. Epub 2011 Sep 13. Chem Rev. 2011. PMID: 21913633 Free article. Review. No abstract available.
Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.
Amaral PA, Autheman D, de Melo GD, Gouault N, Cupif JF, Goyard S, Dutra P, Coatnoan N, Cosson A, Monet D, Saul F, Haouz A, Uriac P, Blondel A, Minoprio P. Amaral PA, et al. Among authors: blondel a. PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006853. doi: 10.1371/journal.pntd.0006853. eCollection 2018 Oct. PLoS Negl Trop Dis. 2018. PMID: 30372428 Free PMC article.
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.
Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I. Harigua-Souiai E, et al. Among authors: blondel a. PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0006160. doi: 10.1371/journal.pntd.0006160. eCollection 2018 Jan. PLoS Negl Trop Dis. 2018. PMID: 29346371 Free PMC article.
The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites.
Abdelkrim YZ, Harigua-Souiai E, Barhoumi M, Banroques J, Blondel A, Guizani I, Tanner NK. Abdelkrim YZ, et al. Among authors: blondel a. Mol Biochem Parasitol. 2018 Dec;226:9-19. doi: 10.1016/j.molbiopara.2018.10.001. Epub 2018 Oct 23. Mol Biochem Parasitol. 2018. PMID: 30365976 Free article.
145 results