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The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid.
Varela Chavez C, Hoos S, Haustant GM, Chenal A, England P, Blondel A, Pauillac S, Lacy DB, Popoff MR. Varela Chavez C, et al. Among authors: blondel a. Cell Microbiol. 2015 Oct;17(10):1477-93. doi: 10.1111/cmi.12449. Epub 2015 May 13. Cell Microbiol. 2015. PMID: 25882477
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.
Martinez M, Batista FA, Maurel M, Bouillon A, Ortega Varga L, Wehenkel AM, Le Chevalier-Sontag L, Blondel A, Haouz A, Hernandez JF, Alzari PM, Barale JC. Martinez M, et al. Among authors: blondel a. Acta Crystallogr D Struct Biol. 2023 Aug 1;79(Pt 8):721-734. doi: 10.1107/S2059798323004710. Epub 2023 Jul 10. Acta Crystallogr D Struct Biol. 2023. PMID: 37428845
The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites.
Abdelkrim YZ, Harigua-Souiai E, Barhoumi M, Banroques J, Blondel A, Guizani I, Tanner NK. Abdelkrim YZ, et al. Among authors: blondel a. Mol Biochem Parasitol. 2018 Dec;226:9-19. doi: 10.1016/j.molbiopara.2018.10.001. Epub 2018 Oct 23. Mol Biochem Parasitol. 2018. PMID: 30365976 Free article.
Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.
Amaral PA, Autheman D, de Melo GD, Gouault N, Cupif JF, Goyard S, Dutra P, Coatnoan N, Cosson A, Monet D, Saul F, Haouz A, Uriac P, Blondel A, Minoprio P. Amaral PA, et al. Among authors: blondel a. PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006853. doi: 10.1371/journal.pntd.0006853. eCollection 2018 Oct. PLoS Negl Trop Dis. 2018. PMID: 30372428 Free PMC article.
145 results