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Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF. Legru A, et al. Among authors: blondel a. Eur J Med Chem. 2024 Apr 5;269:116308. doi: 10.1016/j.ejmech.2024.116308. Epub 2024 Mar 11. Eur J Med Chem. 2024. PMID: 38503166
Measurements of neutrino oscillation parameters from the T2K experiment using 3.6×1021 protons on target.
Abe K, Akhlaq N, Akutsu R, Ali A, Alonso Monsalve S, Alt C, Andreopoulos C, Antonova M, Aoki S, Arihara T, Asada Y, Ashida Y, Atkin ET, Barbi M, Barker GJ, Barr G, Barrow D, Batkiewicz-Kwasniak M, Bench F, Berardi V, Berns L, Bhadra S, Blanchet A, Blondel A, Bolognesi S, Bonus T, Bordoni S, Boyd SB, Bravar A, Bronner C, Bron S, Bubak A, Buizza Avanzini M, Caballero JA, Calabria NF, Cao S, Carabadjac D, Carter AJ, Cartwright SL, Catanesi MG, Cervera A, Chakrani J, Cherdack D, Chong PS, Christodoulou G, Chvirova A, Cicerchia M, Coleman J, Collazuol G, Cook L, Cudd A, Dalmazzone C, Daret T, Davydov YI, De Roeck A, De Rosa G, Dealtry T, Delogu CC, Densham C, Dergacheva A, Di Lodovico F, Dolan S, Douqa D, Doyle TA, Drapier O, Dumarchez J, Dunne P, Dygnarowicz K, Eguchi A, Emery-Schrenk S, Erofeev G, Ershova A, Eurin G, Fedorova D, Fedotov S, Feltre M, Finch AJ, Fiorentini Aguirre GA, Fiorillo G, Fitton MD, Franco Patiño JM, Friend M, Fujii Y, Fukuda Y, Fusshoeller K, Giannessi L, Giganti C, Glagolev V, Gonin M, González Rosa J, Goodman EAG, Gorin A, Grassi M, Guigue M, Hadley DR, Haigh JT, Hamacher-Baumann P, Harris DA, Hartz M, Hasegawa T, Hassani S, Hastings NC, Hayato Y, Hena… See abstract for full author list ➔ Abe K, et al. Among authors: blondel a. Eur Phys J C Part Fields. 2023;83(9):782. doi: 10.1140/epjc/s10052-023-11819-x. Epub 2023 Sep 5. Eur Phys J C Part Fields. 2023. PMID: 37680254 Free PMC article.
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.
Martinez M, Batista FA, Maurel M, Bouillon A, Ortega Varga L, Wehenkel AM, Le Chevalier-Sontag L, Blondel A, Haouz A, Hernandez JF, Alzari PM, Barale JC. Martinez M, et al. Among authors: blondel a. Acta Crystallogr D Struct Biol. 2023 Aug 1;79(Pt 8):721-734. doi: 10.1107/S2059798323004710. Epub 2023 Jul 10. Acta Crystallogr D Struct Biol. 2023. PMID: 37428845
Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus.
Abdelkrim YZ, Harigua-Souiai E, Bassoumi-Jamoussi I, Barhoumi M, Banroques J, Essafi-Benkhadir K, Nilges M, Blondel A, Tanner NK, Guizani I. Abdelkrim YZ, et al. Among authors: blondel a. Molecules. 2022 Sep 10;27(18):5890. doi: 10.3390/molecules27185890. Molecules. 2022. PMID: 36144626 Free PMC article.
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.
Chen KY, Krischuns T, Varga LO, Harigua-Souiai E, Paisant S, Zettor A, Chiaravalli J, Delpal A, Courtney D, O'Brien A, Baker SC, Decroly E, Isel C, Agou F, Jacob Y, Blondel A, Naffakh N. Chen KY, et al. Among authors: blondel a. Antiviral Res. 2022 May;201:105272. doi: 10.1016/j.antiviral.2022.105272. Epub 2022 Mar 9. Antiviral Res. 2022. PMID: 35278581 Free PMC article.
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
Papaioannou A, Centonze F, Metais A, Maurel M, Negroni L, Gonzalez-Quiroz M, Mahdizadeh SJ, Svensson G, Zare E, Blondel A, Koong AC, Hetz C, Pedeux R, Tremblay ML, Eriksson LA, Chevet E. Papaioannou A, et al. Among authors: blondel a. Life Sci Alliance. 2022 Feb 22;5(5):e202201379. doi: 10.26508/lsa.202201379. Print 2022 May. Life Sci Alliance. 2022. PMID: 35193953 Free PMC article.
145 results